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Table 4 Pathways with up- or down-regulated genes after syngeneic transplantation or allogeneic transplantation. Pathway charts were obtained using DAVID functional annotation tools (p < 0.05, Fisher's exact test, p-value with Benjamini correction). Pathways with a significantly elevated number of genes down- or up-regulated after syngeneic transplantation (sTX) or allogeneic transplantation (aTX) compared to control are shown Table 4. The numbers indicate the genes affected within the pathways.

From: Activation of counter-regulatory mechanisms in a rat renal acute rejection model

sTX-down   sTX-up  
Pathway Count Pathway Count
tryptophan metabolism 13 ribosome 22
methionine metabolism 7 cell cycle 28
valine, leucine and isoleucine degradation 11 ribosome 13
lysine degradation 9 focal adhesion 31
fatty acid metabolism 11 ecm-receptor interaction 16
pyruvate metabolism 9 cell communication 16
beta-alanine metabolism 7   
propanoate metabolism 8   
butanoate metabolism 9   
selenoamino acid metabolism 6   
caprolactam degradation 5   
alkaloid biosynthesis II 5   
limonene and pinene degradation 5   
glycine, serine and threonine metabolism 7   
aTX-down   aTX-up  
Pathway Count Pathway Count
oxidative phosphorylation 48 antigen processing and presentation 46
fatty acid metabolism 29 ribosome 43
valine, leucine and isoleucine degradation 25 cell cycle 50
glutathione metabolism 21 proteasome 22
citrate cycle (tca cycle) 13 t cell receptor signaling pathway 45
pyruvate metabolism 17 type I diabetes mellitus 28
butanoate metabolism 20 hematopoietic cell lineage 33
glycine, serine and threonine metabolism 17 cell adhesion molecules (cams) 50
metabolism of xenobiotics by cytochrome p450 23 cytokine-cytokine receptor interaction 48
tryptophan metabolism 21 toll-like receptor signaling pathway 26
propanoate metabolism 14   
reductive carboxylate cycle (CO2 fixation) 6