Activation of counter-regulatory mechanisms in a rat renal acute rejection model

BMC Genomics

Table 4 Pathways with up- or down-regulated genes after syngeneic transplantation or allogeneic transplantation. Pathway charts were obtained using DAVID functional annotation tools (p < 0.05, Fisher's exact test, p-value with Benjamini correction). Pathways with a significantly elevated number of genes down- or up-regulated after syngeneic transplantation (sTX) or allogeneic transplantation (aTX) compared to control are shown Table 4. The numbers indicate the genes affected within the pathways.

sTX-down		sTX-up
Pathway	Count	Pathway	Count
tryptophan metabolism	13	ribosome	22
methionine metabolism	7	cell cycle	28
valine, leucine and isoleucine degradation	11	ribosome	13
lysine degradation	9	focal adhesion	31
fatty acid metabolism	11	ecm-receptor interaction	16
pyruvate metabolism	9	cell communication	16
beta-alanine metabolism	7
propanoate metabolism	8
butanoate metabolism	9
selenoamino acid metabolism	6
caprolactam degradation	5
alkaloid biosynthesis II	5
limonene and pinene degradation	5
glycine, serine and threonine metabolism	7
aTX-down		aTX-up
Pathway	Count	Pathway	Count
oxidative phosphorylation	48	antigen processing and presentation	46
fatty acid metabolism	29	ribosome	43
valine, leucine and isoleucine degradation	25	cell cycle	50
glutathione metabolism	21	proteasome	22
citrate cycle (tca cycle)	13	t cell receptor signaling pathway	45
pyruvate metabolism	17	type I diabetes mellitus	28
butanoate metabolism	20	hematopoietic cell lineage	33
glycine, serine and threonine metabolism	17	cell adhesion molecules (cams)	50
metabolism of xenobiotics by cytochrome p450	23	cytokine-cytokine receptor interaction	48
tryptophan metabolism	21	toll-like receptor signaling pathway	26
propanoate metabolism	14
reductive carboxylate cycle (CO2 fixation)	6

ISSN: 1471-2164