Table 1 Differentially expressed genes in the mouse liver after fasting (Sterolgene v0 microarray). Differentially expressed genes in the mouse liver after fasting as detected by the Sterolgene array (α = 0.05).
Gene name and function | Gene symbol | Log2 ratio | GeneBank Acc. No. |
|---|---|---|---|
Cholesterol biosynthesis | |||
Acetyl-CoA acetyltransferase 2 | Acat2 | -1.13 | NM_009338 |
Mevalonate kinase | Mvk | -0.56 | NM_023556 |
Lanosterol 14α-demethylase | Cyp51a1 | -1.32 | BC031813 |
Sterol-C4-methyl oxidase-like | Sc4mol | -2.05 | NM_025436 |
NAD(P) dependent steroid | Nsdhl | -1.47 | BC019945 |
dehydrogenase-like | |||
Sterol C5 desaturase | Sc5d | -1.75 | BC024132 |
Bile acid biosynthesis | |||
Sterol 12α-hydroxylase | Cyp8b1 | 0.49 | NM_010012 |
Cytochrome P450 superfamily | |||
Cytochrome P450, 1a2 | Cyp1a2 | -1.35 | NM_009993 |
Cytochrome P450, 3a25 | Cyp3a25 | -0.78 | BC028855 |
Cytochrome P450, 3a41 | Cyp3a41 | -1.91 | NM_017396 |
Cholesterol side chain cleavage enzyme | Cyp11a1 | 0.41 | NM_019779 |
Retionic acid hydrolase | Cyp26a1 | -0.83 | NM_007811 |
Nuclear receptor superfamily | |||
Peroxisome proliferator-activated | Nr1c1 | -1.03 | NM_011144 |
receptor alpha | |||
Retinoic acid-related orphan | Nr1f3 | -0.60 | NM_011281 |
receptor gamma | |||
Retinoic acid-related orphan | Nr1f1 | -0.54 | NM_013646 |
receptor alpha | |||
Liver X receptor beta | Nr1h2 | -0.46 | NM_009473 |
Constitutive androstane receptor | Nr1i3 | 0.22 | NM_009803 |
Transcription factors | |||
Sterol regulatory element binding transcription factor 2 | Srebp2 | -0.60 | NM_033218 |
CCAAT/enhancer binding protein alpha | Cebpa | -0.38 | BC028890 |
Transcription factor 1 | Tcf1 | 0.17 | NM_009327 |
Other | |||
Peptidylprolyl isomerase A | Ppia | -0.65 | NM_008907 |
Organic anion transporter 1 | Slco1a1 | -0.55 | AY195868 |
Delta-aminolevulinate synthase 1 | Alas1 | 0.98 | NM_020559 |