Table 4 Differentially expressed genes in the mouse liver after cholesterol feeding (Sterolgene v0 microarray). Differentially expressed genes in the mouse liver after cholesterol feeding as detected by the Sterolgene array (α = 0.1).
Gene name and function | Gene symbol | Log2 ratio | GeneBank Acc. No. |
|---|---|---|---|
Cholesterol biosynthesis | |||
Acetyl-Coenzyme A synthetase 2 | Acas2 | -2.35 | NM_019811 |
Phosphomevalonate kinase | Pmvk | -1.18 | NM_026784 |
Farnesyl diphosphate farnesyl transferase 1 | Fdft1 | -2.46 | NM_010191 |
Squalene epoxidase | Sqle | -2.47* | BC042781 |
Lanosterol 14α-demethylase | Cyp51a1 | -1.90 | BC031813 |
NAD(P) dependent steroid dehydrogenase-like | Nsdhl | -2.06* | BC019945 |
Bile acids biosynthesis | |||
Cholesterol 7α-hydroxylase | Cyp7a1 | -1.44* | NM_007824 |
Cytochrome P450, 7b1 | Cyp7b1 | -2.01* | BC038810 |
Cholesterol transport | |||
LDL receptor adaptor protein 1 | Ldlrap1 | 0.76 | NM_145554 |
Sterol carrier protein 2 | Scp2 | 1.09* | BC018384 |
Nuclear receptor superfamily | |||
Small heterodimeric partner | Nr0b2 | 0.94* | NM_011850 |
Testis receptor | Nr2c1 | 0.60* | NM_011629 |
Glucocorticoid receptor | Nr3c1 | 0.83* | NM_008173 |
Cytochrome P450 superfamily – xenobiotic metabolism | |||
Cytochrome P450, 2g1 | Cyp2g1 | 1.09 | NM_013809 |
Cytochrome P450, 3a41 | Cyp3a41 | 1.92 | NM_017396 |