Figure 1
From: Dissecting microregulation of a master regulatory network
Four possible scenarios for the upstream regulators (A-D) and downstream targets (E-H) of p53. For the downstream coherent models, the p53 action on downstream target gene and miRNA is opposite (F and H). In case of downstream incoherent models (E and G), the p53 action on downstream target gene and miRNA is same. There may be a sequential gap in the activation time of the target gene and miRNA facilitating maintenance of steady states.