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Table 1 p53-miRs (microRNAs which have a conserved p53 binding site in their flanking 10 kb genomic sequence) which putatively target known transcription factors that are either upstream or downstream to p53 network (based on p53 knowledge base [36]) (A: activator; R: Repressor; U: uncharacterized). Only those targets are shown that are predicted as miRNA targets by 2 or more than two algorithms. miRNAs that are in bold represent miRNAs induced more than 1.5 fold (p < 0.05) after p53 activation [11]. The last column indicates whether a miRNA has been reported in literature as differentially expressed in cancer or cancer cell lines.

From: Dissecting microregulation of a master regulatory network

miRNA TF TargetScanS miRanda microT miRtarget picTar Relation to p53 (Interaction Type) [20] Differentially expressed in cancer
hsa-miR-183 EGR1 + + - + - Upstream (A) Yes
hsa-miR-26b HOXA5 + - - + - Upstream (A) Yes
hsa-miR-96 HOXA5 + - - + - Upstream (A) Yes
hsa-miR-376a HOXA5 - + + - - Upstream (A) No
hsa-miR-376b HOXA5 - + + - - Upstream (A) No
hsa-miR-181c FOS + + - + - Upstream (A/R) Yes
hsa-miR-222 FOS + + - - - Upstream (A/R) Yes
hsa-miR-101 FOS + + - + - Upstream (A/R) No
hsa-miR-10a BCL6 + + - - - Upstream (R) Yes
hsa-miR-124a KLF4 + - - + - Upstream (R) Yes
hsa-miR-148a KLF4 + + + + - Upstream (R) Yes
hsa-miR-32 KLF4 + + - + - Upstream (R) Yes
hsa-miR-34a KLF4 + - - + - Upstream (R) Yes
hsa-miR-7 KLF4 + - - + - Upstream (R) Yes
hsa-miR-508 KLF4 - + - + - Upstream (R) No
hsa-miR-155 CEBPB + + + - - Upstream (U) Yes
hsa-miR-27a BTG2 + + + - - Downstream (A) Yes
hsa-miR-32 BTG2 + + - - - Downstream (A) Yes
hsa-miR-27a CCNG1 + - - + - Downstream (A) Yes
hsa-miR-122a CCNG1 + + - + - Downstream (A) Yes
hsa-miR-33 EEF1A1 + + - - - Downstream (A) No
hsa-miR-502 GADD45A - + - + - Downstream (A) No
hsa-miR-19b IGFBP3 + + - - - Downstream (A) Yes
hsa-miR-29a MMP2 - + - + - Downstream (A) Yes
hsa-miR-29b MMP2 - + - + - Downstream (A) Yes
hsa-miR-29c MMP2 - + - + - Downstream (A) Yes
hsa-miR-128b PLK2 + + - + + Downstream (A) Yes
hsa-miR-200b PLK2 + + - + - Downstream (A) Yes
hsa-miR-200c PLK2 + + - + - Downstream (A) Yes
hsa-miR-27a PLK2 + + - + + Downstream (A) Yes
hsa-miR-30b SERPINE1 + + + + - Downstream (A) Yes
hsa-miR-30c SERPINE1 + + + + - Downstream (A) Yes
hsa-miR-34a SERPINE1 + - - + - Downstream (A) Yes
hsa-miR-192 RB1 + + - - - Downstream (A/R) Yes
hsa-miR-200b ANLN + + - - - Downstream (R) Yes
hsa-miR-200c ANLN + + - - - Downstream (R) Yes
hsa-miR-142-3p IER3 - + - + - Downstream (R) Yes
hsa-miR-124a SCD + - - + - Downstream (R) Yes