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Table 3 Top 25 most significant p53-miRs that target known cell proliferation genes (n = 712). 22/25 of these have been reported in literature as differentially regulated in various cancerous tissues or cancer cell lines (see last column). The p-values represent the probability of a p53-miR targeting a cell proliferation gene purely by chance.

From: Dissecting microregulation of a master regulatory network

miRNA Total Number of Predicted Targets Cell Proliferation Genes (n = 712) Genes p-value Cancer miRNA
hsa-miR-23a 656 44 ALDH1A2, BCL11B, CBFA2T2, CBFA2T3, CDC6, CDK5R1, CFDP1, CSE1L, CTNNBIP1, CUL3, CXCL5, ELF4, ELF5, EPS15, GPC4, HDGFRP3, HOXA3, IHH, IL11, IL6R, IRF2, KITLG, LRP5, MAPRE1, MDK, MET, MLLT7, NAP1L1, NOTCH2, NPM1, NR6A1, ODZ1, OPRM1, PRKRIR, PTK2B, RAP1B, SMAD3, SPOCK1, STAT5B, TGFA, TOB2, TRIB1, TUSC2, ZAK 8.42E-10 Yes
hsa-miR-92 614 41 ADM, AGGF1, APRIN, BMPR2, BRCA1, BTG2, CBFA2T3, CDC27, CDK6, CDKN1C, CTNNBIP1, CUL3, CXCL5, DERL2, DLG5, EDG1, EPS8, GDF11, HHIP, IGF1R, INSIG1, IRS2, KLF4, LBX1, MITF, NCK2, NF1, NOTCH1, NOX4, PAFAH1B1, PAX3, PCAF, RAP1B, RBM9, SPHK2, TBX3, TCFL5, TOB1, TOB2, UTP20, ZAK 3.64E-09 Yes
hsa-miR-32 630 39 ADM, AGGF1, APRIN, BMPR2, BTG2, BTLA, CBFA2T3, CDK6, CDKN1C, CHRM5, CTNNBIP1, CUL3, CXCL5, EDD1, EDG1, EPS8, EVI5, GDF11, HHIP, INSIG1, IRS2, KLF4, LBX1, MITF, NCK2, NOTCH1, NOX4, PAFAH1B1, PAX3, PCAF, RAP1B, RBM9, SPHK2, TBX3, TCFL5, TOB1, TOB2, TTK, ZAK 6.67E-08 Yes
hsa-miR-200b 737 42 APRIN, BAP1, BCL11B, BHLHB3, CD274, CDC25B, CNOT8, CNTFR, CTBP2, EDNRA, EPS8, ETS1, EVI5, GAB1, GLI3, HDAC4, HELLS, HGF, IL1A, KHDRBS1, KLF10, KLF4, LAMC1, LRP1, LRPAP1, MAFG, MAPRE1, MXD4, MYC, NCK2, NDN, NPM1, PCAF, POU3F2, PROK2, PTHLH, RAP1B, SESN1, SHC1, STAT5A, SUZ12, TOB1 2.02E-07 Yes
hsa-miR-200c 751 42 APRIN, BAP1, BCL11B, BHLHB3, BIN1, CD274, CNOT8, CNTFR, CTBP2, EDNRA, EPS8, ETS1, EVI5, GAB1, GLI3, GNAT1, HDAC4, HELLS, HGF, KHDRBS1, KLF10, KLF4, LAMC1, LRP1, LRPAP1, MAFG, MAPRE1, MXD4, MYC, NCK2, NDN, NPM1, PCAF, POU3F2, PROK2, PTHLH, RAP1B, SCG2, SESN1, SHC1, STAT5A, TOB1 3.33E-07 Yes
hsa-miR-195 766 42 ALOX12, AXIN2, BAI1, BDNF, BHLHB3, BIN1, BTG2, CBFA2T3, CD164, CD28, CD40, CDC25A, CDC27, CDK5R1, CHEK1, CUL2, DNAJA2, EFNB1, FGF2, FGF7, FOSL1, HDGF, HOXA3, LAMC1, MAPRE1, MNT, MTCP1, NF2, PAFAH1B1, PDAP1, PIM1, POU3F2, PPAP2A, PPM1D, PRDM4, PRKCD, PTHLH, PURB, RAF1, RARRES1, SESN1, SPEG 5.60E-07 Yes
hsa-miR-10a 230 20 BCAR1, BCL6, BDNF, CDK4, CTNNBIP1, FLT1, HDAC4, HOXA3, ID4, IFNAR2, JARID2, KLF11, KLF4, MAPRE1, PAFAH1B1, PURB, SERTAD1, SHC1, TRAIP, ZMYND11 7.09E-07 Yes
hsa-miR-10b 237 20 BCAR1, BCL6, BDNF, CDK4, CNOT8, CTNNBIP1, FLT1, HDAC4, HOXA3, ID4, IFNAR2, JARID2, KLF11, KLF4, MAPRE1, PAFAH1B1, PURB, SHC1, TRAIP, ZMYND11 1.14E-06 Yes
hsa-miR-24 445 29 ADM, CD164, CD28, CDK5, CDKN1B, CDV3, CNTFR, CSF2, CSK, DCTN2, EDG1, FLT1, GPC4, ING5, INSIG1, MAFG, MNT, MXI1, NUDC, PDGFRA, PIM1, PIM2, PURB, RAP1B, SERTAD1, SESN1, SPHK1, TOB2, ZNF259 1.16E-06 Yes
hsa-miR-203 505 31 ALDH1A2, BCL11B, CASP3, CNTFR, DLG5, EDD1, EDN1, EDNRA, FGG, GLI3, HBEGF, ID4, INSIG1, IRS2, KHDRBS1, MAPRE1, NUMBL, PDAP1, PDGFRA, PPM1D, PRKRIR, PURB, RERG, SMAD1, SMAD3, TBX3, TGFB2, TNFRSF8, TUSC2, USP8, ZMYND11 1.77E-06 Yes
hsa-miR-124a 1333 60 ANXA7, AR, BCL11B, BCL6, BTG2, CAPN1, CAV1, CD164, CD276, CDK6, CDKN1A, CUL5, DLG5, DLG7, EFNB1, EMP2, EPS8, ERF, ETS1, EVI1, EVI5, FGFR1OP, GAS1, GNAI2, GPC4, HDAC4, IL9R, ING1, JAG1, JAG2, KLF4, LAMC1, MAP3K11, MAPRE1, MDK, MITF, MXD4, NCK2, NRP1, OVOL2, PAFAH1B1, PBEF1, PDZK1, PGF, PIM1, PRKD1, PTHLH, PURB, QSCN6, RAF1, RAP1B, RARRES1, RHOG, SHC1, SOX9, SPHK1, SPOCK1, TAL1, TOB2, UHRF1 1.82E-06 Yes
hsa-miR-106a 751 40 BCL11B, BCL6, BHLHB3, BMPR2, BTG1, BTG2, BTG3, CDKN1A, COL4A3, CSF1, DERL2, E2F1, EBI3, EDD1, EDG1, EFNB1, EREG, FLT1, FZD3, GAB1, HDAC4, KLF11, LIF, MAP3K11, MAPRE1, PAFAH1B1, PCAF, PDGFRA, PPARD, PTEN, PTHLH, PURB, RB1, RBBP7, TAL1, TBX3, TGFB1, TOPORS, TSG101, TUSC2, 2.13E-06 Yes
hsa-miR-142-3P 364 25 BTG4, BUB1B, CDC14A, CDC25C, CRTAM, EDG3, EHF, ERG, FGFR1OP, FNTB, FOXO1A, FRK, GRN, IL6, IL6ST, KHDRBS1, KLF10, MAP3K11, MLLT7, NUMBL, PCAF, PURB, SKP2, TNFRSF13C, UTP20, 2.50E-06 Yes
hsa-miR-33 312 22 APRIN, BCL11B, BMPR2, CD40, CDK6, CKS2, DOCK2, FGA, FGFBP1, HIPK2, HOXC10, IRS2, LGI1, LMO1, NPM1, NPY, PDGFRA, PIM1, PURB, RB1, TSG101, UBE2V2, 6.53E-06 No
hsa-miR-372 378 24 BCL6, BTG1, CDCA7, CDK2, CXCR4, DERL2, DNAJA2, E2F1, ERBB4, FGF9, FRK, IRF2, MAP3K11, MNT, PCAF, PRDM4, PURB, RBBP7, TAL1, TOB2, TUSC2, UCHL1, ZFP36L2, ZMYND11, 1.47E-05 Yes
hsa-miR-101 627 33 BUB1B, CALCRL, CBFA2T2, CD28, CDC14A, CDC27, CDH5, CDK5R1, CDK6, CSRP2, CUL3, DLG5, ELN, EMP1, FGA, FOXO1A, GLI3, GNB1, ING4, PAX3, PBEF1, PPBP, PPP1R8, PURA, PURB, RAP1B, RBBP7, SOX9, STAMBP, TAL1, TCF19, TGFBR1, TRIB1, 2.09E-05 No
hsa-miR-19b 715 36 ANXA7, BMPR2, CD164, CDC2L5, CHERP, CLK1, CNTFR, CSE1L, CUL5, DLG5, DNAJA2, EDG1, EPS15, ERBB4, EREG, FOSL1, GCG, GRN, HDAC4, HHIP, HPRT1, ID4, IGF1, IMPDH1, KLF10, LIF, PCAF, POU3F2, PTK2B, RAF1, RAP1B, SMARCA2, SPHK2, ST8SIA1, SUZ12, ZMYND11 2.29E-05 Yes
hsa-miR-196a 243 18 ACSL6, ANXA1, ATP6AP1, CASP3, CBFA2T3, CCL23, CDKN1B, ELF4, ERG, IGFBP7, ING5, MYC, NFKBIA, PA2G4, PDGFRA, SSR1, UHRF2, ZMYND11 2.30E-05 Yes
hsa-miR-26b 633 33 ADM, BCL6, BTG1, CDC27, CDC2L5, CDK6, CKS2, DLG5, DNAJA2, ENPEP, EPS15, ERBB4, HGF, HIPK2, HOXD13, IGF1, IL6, JAG1, KLF10, KLF4, LIF, MITF, MXI1, PAWR, PBEF1, PDGFRA, PIM1, PRKCD, PRKCQ, PTEN, SMAD1, SMAD4, TOB1, 2.52E-05 Yes
hsa-miR-196b 245 18 ACSL6, ANXA1, ATP6AP1, CBFA2T3, CCL23, CDKN1B, ELF4, ERG, FOXN1, IGFBP7, ING5, MYC, NF2, NFKBIA, PA2G4, PDGFRA, SSR1, ZMYND11 2.57E-05 Yes
hsa-miR-9 737 36 ARHGEF2, BCL6, BIN1, BTG2, CBFA2T2, CNTFR, COL18A1, CUL4A, CXCR4, EDD1, ERG, ETS1, FGF5, FOXO1A, HDAC4, HES1, ID4, INSIG1, KITLG, LEPRE1, LIFR, NAP1L1, NOTCH2, NOX4, NRP1, ODZ1, PDGFC, PMP22, POU3F2, PPARD, RAP1B, RBM9, SHC1, TBC1D8, TGFBI, UHRF1 4.29E-05 Yes
hsa-miR-29b 541 29 BAX, BCL11B, CAV2, CD40, CDC7, CREG1, DUSP22, EPS15, FRAT2, FSCN1, GAB1, HDAC4, INSIG1, JARID2, LAMC1, MAFG, NASP, PDGFB, PDGFC, PINX1, PMP22, PPM1D, PRKRA, PTEN, SETDB1, SMARCA2, SPEG, TNFRSF9, UHRF2 4.71E-05 Yes
hsa-miR-200a 634 32 APRIN, ATP8A2, BAP1, BIN1, CD274, CDC14A, CDC25A, CDC25B, CDC2L5, CDK6, CSF3, CTBP2, CTNNB1, CUL3, FLT1, GAB1, HDAC4, HGF, IL1A, IRS2, JAG1, NME1, NRP1, PAX3, PBEF1, POU3F2, PRKD1, SCG2, STAT4, STAT5A, STAT5B, TGFB2 6.15E-05 Yes
hsa-miR-34a 666 33 AREG, ARX, BCL11B, BCL6, CBFA2T3, CD28, CD3E, CDC25A, CSF1R, EFNB1, ENPP7, FOSL1, GFER, GNAI2, IL6R, JAG1, KITLG, KLF4, LGI1, MET, MOV10L1, NOTCH1, NOTCH2, NUMBL, PDGFRA, PGF, PRKD1, PURB, SPEG, TGFBI, TOB2, TOPORS, UHRF2 6.76E-05 Yes
hsa-miR-181c 824 38 ABI1, ADAMTS1, ADM, ARHGEF2, BCL6, BMPR2, CALCRL, CBFA2T2, CBFA2T3, CKS1B, CUL3, EDG1, EPS15, ERF, ERG, ETS1, FLT1, IL1A, IRS2, LIF, LMO1, NOTCH2, NR6A1, PAFAH1B1, PAWR, PCAF, PDAP1, PDGFRA, PRDM4, PRKCD, PURB, RAP1B, RBBP7, TGFBI, TGFBR1, TGFBR2, USP8, VIP 8.89E-05 Yes