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Figure 3 | BMC Genomics

Figure 3

From: Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family

Figure 3

Homology modelling of representative group 1 and group 2 SmVAL proteins demonstrates the SCP/TAPS domain of both groups possess an α-β-α tertiary structure with a large surface cleft containing the proposed family active site. Models were constructed for all SmVAL SCP/TAPS domains using MODELLER as described in Methods and are represented here by SmVAL1 (group 1, panels A and C) and SmVAL13 (group 2, panels B and D). A cartoon representation of the core α-β-α sandwich structure is coloured in red for SmVAL1 (A) and blue for SmVAL13 (B). Conserved cysteines and the disulphide bonds are coloured yellow, with the cysteines involved in the formation of each disulphide bond labelled C1-C6. The two regions I1 (insertion) and D1 (deletion) are coloured white on each structure. Panel C (SmVAL1) and D (SmVAL13) are semi-transparent visualisations of the protein surface with the four putative active site residues shown in white.

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