Table 4 2 × 2 Table for testing whether pathway j was over-represented in the identified genes (To test H0: the number of genes in pathway p is independent of the number of identified genes relevant to CAN. Vs. H1: the number of genes in pathway p is over-represented in the identified genes relevant to CAN, since all the marginal values are given, Fisher's exact test is used. The p-value from the test is , where gID, pdenotes the observed value of GID, p)