Figure 7
A. Example images of compact and aggregate spheroid structures derived from OC cells. B. Hierarchical clustering of OC spheroids following treatment with all used drugs (cisplatin, topotecan and paclitaxel (taxol)), that discriminates between compact spheroids and aggregates. A subset of candidate genes were initially obtained by filtering on signal intensity (2-fold), retaining 527 genes. One-way ANOVA parametric test (Welch t-test, variances not assumed equal, p ≤ 0.03) further selected 85 genes. Clustering analysis based on the 85 gene list was performed using the standard Condition Tree algorithm provided in GeneSpring. The mean appears grey, whereas red signifies up-regulation, and green signifies down-regulation (see legend bar). Compact spheroids are indicated in brown, aggregates are indicated in grey. Each cell line is indicated with different color.