Table 4 Selected differentially expressed gene groups upon cisplatin treatment.
A. Up-regulated genes | |
|---|---|
Apoptosis | DNAJA3, EMP1, PERP, PHLDA2, ZNF443, BCL2A1, APAF1, CASP3, CASP7, FADD, PPP2CA |
Cell growth and proliferation | DSN1, MIS12, MND1, SPATA5L1, DCC1, HELLS, ANXA1, NUSAP1, Spc25, TGFA, TYMS, UHRF1, EZH2 |
DNA replication and repair | BRCA1, CHAF1B, EXO1, MSH2, NEIL3, PCNA, POLQ, RAD51AP1, UBE2A, PRIM2A, MCM10, MCM2, MCM3, MCM4, POLA2, POLE3, PRIM1, RRM1, RRM2 |
Cell cycle | ZWINT, SEPT10, CDC2, CDC45L, CDCA5, CNNM4, E2F8, GNL3, PKMYT1, PPP6C |
Cell cycle arrest | BTG3, CDKN1A, GMNN, HIS1, RECK, CDKN2D |
Cell adhesion | CLDN2, TNXB, GJA10, EMP1, ANKRD32 |
Cytoskeleton | PALMD, SDCBP, ANKRD27 |
Regulation of transcription | C16orf34, CBFB, CREM, ELL2, MORC3, NR4A1, PHTF1, RRN3, TRIP13, WDHD1, ZBTB38, ZNF180, ZNF211, ZNF26, ZNF304, ZNF326, ZNF45, ZNF529, ZNF550, DNMT1, EED, TGIF, LHX2 |
Signal transduction | ALS2, ARL6IP6, DEPDC1, JUB, NOC3L, RAB21, RAB2B, RACGAP1, SLAMF1, SMAD3, STMN1, STRN4 |
Transport | C20orf35, CACNB1, GPD2, MFTC, NUP107, PSCD1, SCN2B, Shax3, SLC19A2, SLC25A17, SLC25A17, THOC4 |
B. Down-regulated genes | |
Apoptosis | CARD9, DAPK3, DOCK1, GP9, LTBR, YARS, PRKCZ, TNFRSF6B, DDIT4, CLU, HIPK2, NME3, NUDT2 |
Cell adhesion | BCLAF1, CCDC78, CD151, ITGB3BP, LAMA5, LIMS2, MUC6, SN |
Chromatin organization | H1FX, HIST1H1E, HIST1H2AA, HIST1H3G, HIST1H3H, HMG20B, SAFB |
Cytoskeleton | ACTR1B, CYLN2, DLC1, DNAI2, EML3, TMEM102, KRT6E, ODF2, PDLIM2, SPTBN5, TUBGCP2, VILL |
Immune & inflam-matory response | C1QL1, CD2BP2, CIB3, COLEC11, HES6, HLA-B, HLA-C, HLA-E, HLA-G, KIR3DL3, LAT, OAS3, OTUB1, IRGC, RFX1, TNFRSF13B, NIBP |
Lipid metabolism | ARH, HDLBP, LDLR, LOC197322, PEMT, AGPAT2, CYP11A1, PCCB, PSAP |
Metabolism (other than lipid metabolism) | AKR1C3, ALDOA, B4GALT2, CA5A, CDC42EP1, CLYBL, DHRS10, ENO1B, GMDS, GRHPR, HAGHL, HPD, HSD11B1, HYAL2, IMPDH2, ITIH2, LARGE, LHPP, NDST2, NUDT14, OGDH, P4HB, PRLH, PSMC3, PYGM, RDH13, ST6GALNAC6, TKT |
Protein biosynthesis & modification | ASMTL, C9orf54, CRYL1, EEF1A2, EEF1D, EIF4G1, HOXB8, MRPL12, RPL18, RPS14, RPS2, RPS9, SURF6, TUFM, VARS2, PPP2R4, DUSP15, CKAP1, FKBP2, HKE2, PPIB, ST3GAL3, ADCK1, STK11, KIAA1542 |
Regulation of transcription | PRDM9, ANKRD23, ARID5A, ASCL2, CHST7, COMMD4, DUX4, ENO1, EWSR1, FOXQ1, HLA-A, HOXA10, IL17R, ING5, KEAP1, LBX1, LTBP3, MBD3, MED25, MLLT1, MXD4, MYBBP1A, POLR1A, POLR2E, SIAHBP1, SLC6A8, SUPT3H, TEAD2, VGLL4, ZNF511, ZNF607 |
RNA processing | C20orf14, CPSF3L, DDX49, DHX30, EXOSC6, HNRPAB, LOC144983, MARS, PARN, PPAN, RNASET2, SNRPB, ARL6IP4, CIRBP |
Signal transduction | ADCY2, ADCY5, CABIN1, CALML5, CAMK1, DDEF1, DLL4, EPN1, FZD1, GNA15, GPR37L1, GRAP, GUK1, ITGB1BP2, JAK1, KSR2, MAP2K5, MAPBPIP, MAPKAPK2, NRTN, NSMCE1, OMP, OR2T5, OR2Z1, PIP5K1C, PKIG, PRKCG, PSD, PTPRM, RAP2B, RHO, SPHK1, STOML2, TMEPAI, WNT1 |
Transport | ABCC6, ASNA1, BC-2, CACNA1B, CCS, CORO1A, CYBA, DOT1L, ETFDH, FLJ11749, GRIN2D, HBM, LMAN2, MGC19604, MSCP, NDUFS2, NDUFS6, PP784, SCNN1D, SEC24C, SEC61A1, SEC8L1, SLC12A6, SLC25A29, SLC25A6, SLC2A11, SLC37A1, SNX15, STX10, SYNGR2, TRAPPC6A, GRM4 |