Table 5 Selected differentially expressed gene groups upon topotecan treatment.

Apoptosis

PERP, BAG2, NOL3, PDCD2L, PHLDA2, THAP2, TEGT, CASP3, CASP7, SCOTIN, SMNDC1

Cell growth and proliferation

ASPM, CDCA1, DDX11, KIF2C, MAD2L1BP, NEK2, PLOD3, CALM1, CALM2, CDC2, CSRP2, RARRES3, CDCA5, NUSAP1, CTBP2

Cell cycle

C14orf11, CCDC5, CCNB2, CDC37L1, CDCA2, CKS2, CNNM4, PKMYT1, SNF1LK, TIMELESS, UBE2C, UHRF1, ZWINT, PLK2, SERTAD1

Cell cycle arrest

BTG3, CDKN1A, CDKN2D, HIS1, MFN2, PPM1G, TRIM13, PPM1D

Cell adhesion

ANXA9, GJB1, STRN4, TFPI2, TNXB, GJA10, PCDHB16, C3orf4, CLDN1, CLDN2, ANKRD32

Cytoskeleton

ANXA9, CFL2, CKAP2, KRT8, SDCBP, SLC9A3R1, SPTAN1, TUBB2, TUBB3, WASF1

Defense response

APOBEC3B, CAMLG, UPK3B, ARS2, AHR, HSPA4L, HSPH1, SELS

DNA replication and repair

C1orf124, CRY2, DDB2, NEIL1, PCNA, PTTG1, RAD51AP1, TDG, DUT, POLA2, POLG

Metabolism

ACOX1, CDS1, ELOVL4, GALGT2, PLA2G4C, PLSCR1, ADIPOR1, GOT1L1, ABHD13, ABHD3, ADHFE1, ARPP-19, GLA, GLS2, GYG2, IDS, PGM2, PGM2L1, PPP1R2, PSMA4, RP2, TEX261, DCK, OBFC2A

Protein biosynthesis & modification

ARL6IP, EIF4H, FAM83D, MRPL52, MT-ND3, RPL39, RPLP1, RPS13, RPS29, PPP2CB, PTP4A3, BBS10,, DNAJA5, DNAJB5, DNAJC9, NKTR, PPIC, FUT11, ICMT, KIAA1804, PARP2

Ubiquitination

CBLL1, DTX3L, FBXO5, HSPC150, LOC51136, MYLIP, RFFL, RNF139, RNF6, TRIM21, UBE2D1, UBE2C

Regulation of transcription

SAFB2, TUB, BACH1, BRD8, C7orf11, CCRN4L, CNOT8, DXYS155E, E2F8, FOXA3, GTF2B, KLF5, LHX2, NR4A1, OSR2, PLAGL2, POLR2A, SAP18, SMYD1, SOX10, SOX9, ST18, SUHW3, SUPT16H, SUZ12, TAF12, YEATS2, ZNF211, ZNF318, ZNF326, ZNF92, DNMT1, EED, GMNN, TCEAL1

RNA processing

CSTF2T, DBR1, DDX20, DDX48, FRG1, HEAB, KHSRP, LARP6, PRPF39, RBM26, SF3B4, SLBP, SLU7, ZCCHC8

Signal transduction

CABYR, CGA, DKK1, DLG7, DUSP9, DYRK3, FZD4, IER5, MAPK7, NRAS, OR7E91P, PRKAR1A, RAB2B, RACGAP1, RASSF1, RIT2, RKHD3, RUSC1, STMN1, STRN4, TFPI2, TP53TG3, YWHAB

Transport

AMPH, APBA3, ATP2B3, CLCC1, COG1, CYP2R1, DYNLT1, GGA3, KCNJ9, KCTD10, KPNA2, LAPTM4A, NDUFB2, NETO2, RBM8A, RINT-1, SCN2B, Shax3, SLC19A2, SLC25A17, SLC25A4, SLC9A6, SMOX, TRAM1, TRAPPC4, TXNL5, WDR48, YIF1

Apoptosis

APP, CRYAA, DAPK1, DAPK3, DNM2, DOCK1, FAF1, GULP1, NALP12, TNFRSF12A, TNFRSF6B, WDR9, YARS, BCL2L2, FKSG2, PRKCZ, AIFM3, BCLAF1

Cell adhesion

ALCAM, CASK, CD151, CDA08, CDH2, CLDN18, EIF4G1, FARP1, GJC1, ITGB5, LAMA3, LAMA5, LAMB1, PKP4, ROBO1, SN, TNR, VCL

Cell growth & proliferation

NEK7, CTDSPL, HDGF2, IGF2R, NPDC1, CKLFSF2, AAMP, PRKD1, IL27, NIPSNAP1, PDAP1, PEMT, TPD52L2, ZMYND11, MXD4, IGF1R, LRP16, MT3, MOBKL2B

Cell cycle

CCND1, PCTK2, SEPT6, CDK6, CDK8, CHES1, PLK1, STAG1, EXT1, FHIT

DNA replication and repair

DDIT4, ECGF1, ERCC8, FBXO18, LIG3, MGMT, PRKDC, POLDIP3, SET

Chromatin modification & maintenance

ACTL6B, ANP32B, CHD6, HDAC3, HDAC8, HIST1H1B, HIST1H1E, HIST2H2AC, SAFB, H1FX, HUWE1, SMARCD2, KIAA1797

Cytoskeleton

ARPC1A, C9orf140, CENTG2, CEP170, CYLN2, DIAPH2, DLC1, DLG1, DNCH2, FHOD3, FMNL2, GRM4, ITGB1, KIF21A, MGLL, MID1, ODF2, SNCG, SPIRE1, SPTBN1, SPTBN5, SVIL, ARPC4, FMNL1

Defense response

CBARA1, DEFQ1, GATA3, GNLY, HSPA12B, NOD27, AHSA1, OXR1, STIP1, STK25, STK3, STK39, TLK1, ZAK, GADD45B

Immune & inflam-matory response

AMBP, C1QL1, COLEC11, D2S448, EIF3S8, FN1, HLA-A, HLA-B, HLA-E, IGSF4, IGSF4C, KIR3DL3, MCP, RFX1, RSRC1, TREM1, CCL19

Lipid metabolism

PRKAG1, ACAA1, ARH, CHKA, CRYL1, HMGCS1, INPP5E, LDLR, SBF2, SREBF2, HADHA, CRYL1, DHCR24, HDLBP, PIP5K2A, PITPNM1, PSAP

Metabolism (other than lipid metabolism)

INSR, GANAB, ABHD14B, ACO2, ADK, ADK, AK5, ALDH4A1, ALDOA, ASMTL, B4GALT2, BCDO2, C10orf110, C3orf26, CA5A, CKB, COG5, CROCC, DHRS10, DHRSX, DHRSX, GBE1, HAGHL, HARS2, HHAT, HIBADH, HS3ST3A1, ITIH2, KIAA0100, LARGE, MAT2A, ME1, ME1, MSRA, MVK, NUDT14, NUDT2, PDHA2, PDSS2, PGAM5, PGD, PHGDHL1, PHKB, PIK4CA, PMM2, PPP1R9A, PSMC3, PYGM, raptor, RDH13, SDHA, ST6GALNAC6, SULF2, SUMF1, ACBD6, TIMM44

Protein biosynthesis & modification

ADCY5, EIF2S3, ELP4, LAT, MARS, MRPL12, MRPL12, MRPL23, MRPL28, PARN, RPL10L, RPL22, RPL36, RPL6, RPS14, RPS2, RPS9, RRBP1, SURF6, TUFM, VGLL4, WARS, EEF2, EIF4G3, ATAD3B, BCKDHB, BMPR1A, CDC14B, CKAP1, CYP11A1, DUSP15, FLOT1, IMMP2L, KIAA1542, PAM, PPP2R4, TRIAD3, TRIO, UGCGL2, WNK2, PTPN3, PTPRK, PTPRM, FNTB, CCT7, FKBP8, FKBP9, PPIB, TBCD, ST3GAL4, RFWD2, TTC3

Proteolysis & peptidolysis

ADAM9, ADAMTS7, AFG3L2, CAPN5, COH1, CPD, CTSL, DPP7, PRSS15, PRSS8, PSMB7, PSMB9, SERPINB11, SERPINH1, SIPA1L3, SPPL3, TSP50

Regulation of transcription

TCF25, ADCY2, ARID1B, ARID3A, ASCL2, ATF4, BAZ2B, BBX, BCL6B, BRF1, CALR, CEBPE, COMMD10, DBP, DEAF1, EEF1A2, EWSR1, FOXQ1, HERC2, HES6, HMGA2, IPF1, ITGB3BP, KLF13, LBX1, MED25, MLLT1, MTA1, POLR2E, PRDM9, PSD, PTK2, SLC2A4RG, SMARCA3, SMARCB1, SND1, SOX4, SPDEF, SUPT3H, TBL1XR1, TCF12, TCF8, TEAD2, TEAD4, TGFB1I4, TRPS1, ZFP3, ZNF768, MLLT3, ZFPM1, ZNF193, ZNF214, ZNF271, ZNF306, ZNF503, ZNF511, ZNF521, ZNF543, ZNF569, MAFK

RNA processing

ARL6IP4, CIB3, DDX10, DDX49, DDX56, EIF4B, ENO1B, EXOSC6, HNRPA2B1, HNRPAB, HNRPUL1, KARS, LOC144983, NARS2, PABPC4, QKI, RALY, RNASET2, RNGTT, RPP40, SFRS5, SNRPB, SNRPN

Signal transduction

PPARGC1B, AIG1, AKT1, BRE, C16orf45, C20orf23, CABIN1, CAMK1, CHST7, CSNK1A1, CSNK1A1L, DDEF1, EDG6, EPS15, FZD1, GNAI1, GNAQ, GNB1, GNB2L1, GNG8, GPR172B, GPS1, GRAP, GRK1, HCG9, IL17R, INADL, INPP4B, ITGB1BP2, ITM2C, JAK1, KIAA0174, KRT6E, LMBR1, LPP, MAP2K2, MAP3K4, MAP4K3, MAP4K5, MAPBPIP, MRAS, MYH13, NMBR, NRTN, OMP, OR2T5, OR2Z1, PITPNC1, PKIG, PRKCSH, PRR14, PSTPIP1, PTD004, PTK7, PTK9L, PTPN11, RAB31, RAC3, RAN, RAP2B, RHO, SMAD3, SPHK1, STC2, STOML2, TNFRSF13B, TRABD, TRIM54, USH1C, WNT1, WNT3A, LPHN2

Transport

ABCC1, ABCC4, ABCC6, ACTR1B, ANXA6, AP1S3, ATP5G2, ATP6V0E2, CHMP6, CLIC4, COL4A1, CORO1A, COX7A2L, CYC1, DLG2, DOT1L, EPN1, ETFDH, FLJ10815, FLJ22659, FTHL17, FTL, GABARAP, HBM, ITSN1, KCNJ13, KCNK3, KDELR1, KPNA4, LMAN2, LYRM4, MSCP, NBEA, NDUFA12L, NDUFS2, NDUFS6, NDUFS7, NQO2, PTPRG, R30953_1, RAB1A, RAG2, SCNN1D, SEC14L5, SEC24C, SEC5L1, SEC61A1, SEC8L1, SFXN4, SLC12A6, SLC25A29, SLC37A1, SLC6A8, SNX15, SNX17, SYNE2, THADA, TUSC3, TXN2, TXNDC4, TXNRD1, SLC25A6, FCHSD2