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Table 3 Predicted functional modules of unclassified ORFs.

From: Extending bicluster analysis to annotate unclassified ORFs and predict novel functional modules using expression data

ORF Physical/Genetic Associations (SGD) Functional Evidence
Ribosomal RNA procesing (11.04.01)
YBR271W Localizes to the cytoplasm S-adenosylmethionine-dependent methyltransferase.
YCR016W YGL120C (PRP43) RNA helicase/maturation of rRNA, YPR135W (CTF4) Chromatin-associated protein  
YDL063C YPL131W (RPL5-Protein of (60S) ribosomal subunit) GO ribosome biogenesis & assembly (RCA)
YDL167C (NRP1)   GO ribosome biogenesis & assembly (RCA)
YDR361C (BCP1) Protein component of the large (60S) GO ribosomal large subunit export from nucleus (IMP); Export of Mss4p lipid kinase
YGR187C (HGH1) YDR188W (CCT6-Chaperonin Containing TCP-1) GO ribosome biogenesis & assembly (RCA)
YIL064W   GO ribosome biogenesis & assembly (RCA). S-adenosylmethionine-dependent methyltransferase
YIL096C YLR009W (RLP24) 60S ribosomal subunit biogenesis GO ribosome biogenesis & assembly (RCA)
YIL110W   Putative S-adenosylmethionine-dependent methyltransferase
YIL127C Localizes to the nucleolus GO ribosome biogenesis & assembly (RCA)
YJR003C Detected in purified mitochondria GO ribosome biogenesis & assembly (RCA)
YLR051C (FCF2)   Essential nucleolar protein, 35S rRNA processing
YLR196W (PWP) YPL131W (RPL5-Protein of (60S) ribosomal subunit), YDR188W (CCT6-Chaperonin Containing TCP-1) GO rRNA processing (IMP, ISS)
YLR287C YPR135W (CTF4) Chromatin-associated protein  
YOL022C   Null mutant accumulates 20S pre-rRNA
YOR021C (TSR4)   GO ribosome biogenesis & assembly (RCA)
YOR154W (SLP1)   SUN like protein
YOR252W (TMA16) YLR009W (RLP24) 60S ribosomal subunit biogenesis, YGL120C (PRP43) RNA helicase/maturation of rRNA  
YPL183C   Negative regulation of transposition, RNA-mediated (IMP)
DNA Topology (10.01.02)
YBL112C   Contained within telomere TEL02L, TEL02L-YP
YEL076C   Contained within telomere TEL05L, TEL05L-YP, YEL076C-A
YER189W   Contained within telomere TEL05R, TEL05R-YP
YHR219W   Putative protein of unknown function with similarity to helicases; Contained within telomere TEL08R, TEL08R-YP
Mitochondrial (42.16) & Ribosomal Proteins (12.01.01)
YDR493W   Null mutant displays decreased frequency of mitochondrial genome loss
YKL137W   Mutation results in growth defect on a non-fermentable (respiratory) carbon source
YLR204W Mitochondrial inner membrane protein  
YLR218C   Growth defects on a non-fermentable carbon source
YML030W Localizes to mitochondria Null mutant is viable & displays decreased frequency of mitochondrial genome loss
YMR157C detected in purified mitochondria Displays increased frequency of mitochondrial genome loss
  1. Predicted functional modules of unclassified ORFS. Genetic/Physical interaction and functional evidence supporting predicted functional modules. GO = Gene Ontology; RCA = Reviewed Computational Analysis.