Table 3 Predicted functional modules of unclassified ORFs.
ORF | Physical/Genetic Associations (SGD) | Functional Evidence |
|---|---|---|
Ribosomal RNA procesing (11.04.01) | ||
YBR271W | Localizes to the cytoplasm | S-adenosylmethionine-dependent methyltransferase. |
YCR016W | YGL120C (PRP43) RNA helicase/maturation of rRNA, YPR135W (CTF4) Chromatin-associated protein | |
YDL063C | YPL131W (RPL5-Protein of (60S) ribosomal subunit) | GO ribosome biogenesis & assembly (RCA) |
YDL167C (NRP1) | GO ribosome biogenesis & assembly (RCA) | |
YDR361C (BCP1) | Protein component of the large (60S) | GO ribosomal large subunit export from nucleus (IMP); Export of Mss4p lipid kinase |
YGR187C (HGH1) | YDR188W (CCT6-Chaperonin Containing TCP-1) | GO ribosome biogenesis & assembly (RCA) |
YIL064W | GO ribosome biogenesis & assembly (RCA). S-adenosylmethionine-dependent methyltransferase | |
YIL096C | YLR009W (RLP24) 60S ribosomal subunit biogenesis | GO ribosome biogenesis & assembly (RCA) |
YIL110W | Putative S-adenosylmethionine-dependent methyltransferase | |
YIL127C | Localizes to the nucleolus | GO ribosome biogenesis & assembly (RCA) |
YJR003C | Detected in purified mitochondria | GO ribosome biogenesis & assembly (RCA) |
YLR051C (FCF2) | Essential nucleolar protein, 35S rRNA processing | |
YLR196W (PWP) | YPL131W (RPL5-Protein of (60S) ribosomal subunit), YDR188W (CCT6-Chaperonin Containing TCP-1) | GO rRNA processing (IMP, ISS) |
YLR287C | YPR135W (CTF4) Chromatin-associated protein | |
YOL022C | Null mutant accumulates 20S pre-rRNA | |
YOR021C (TSR4) | GO ribosome biogenesis & assembly (RCA) | |
YOR154W (SLP1) | SUN like protein | |
YOR252W (TMA16) | YLR009W (RLP24) 60S ribosomal subunit biogenesis, YGL120C (PRP43) RNA helicase/maturation of rRNA | |
YPL183C | Negative regulation of transposition, RNA-mediated (IMP) | |
DNA Topology (10.01.02) | ||
YBL112C | Contained within telomere TEL02L, TEL02L-YP | |
YEL076C | Contained within telomere TEL05L, TEL05L-YP, YEL076C-A | |
YER189W | Contained within telomere TEL05R, TEL05R-YP | |
YHR219W | Putative protein of unknown function with similarity to helicases; Contained within telomere TEL08R, TEL08R-YP | |
Mitochondrial (42.16) & Ribosomal Proteins (12.01.01) | ||
YDR493W | Null mutant displays decreased frequency of mitochondrial genome loss | |
YKL137W | Mutation results in growth defect on a non-fermentable (respiratory) carbon source | |
YLR204W | Mitochondrial inner membrane protein | |
YLR218C | Growth defects on a non-fermentable carbon source | |
YML030W | Localizes to mitochondria | Null mutant is viable & displays decreased frequency of mitochondrial genome loss |
YMR157C | detected in purified mitochondria | Displays increased frequency of mitochondrial genome loss |