Short Linear Motifs recognized by SH2, SH3 and Ser/Thr Kinase domains are conserved in disordered protein regions

BMC Genomics

Table 1 Molecular functional groups frequently reported to interact with Domains.

	Molecular function	binding ratio
SH2	Receptor kinase/phosphatase	0.53
	Y kinase-phosphatase	0.51
	Adapter molecule	0.20
	Cell surface receptor	0.14
SH3	Tyr-kinase/phosphatase	0.32
	Adapter molecule	0.18
	Guanine nucleotide exchange factor	0.12
	Cytoskeletal protein	0.11
	GTPase activating protein	0.11
	Molecular function	phospho ratio
Ser/Thr Kinase	Ser/Thr kinase-phosphatase	0.00442
	Cell cycle control protein	0.00397
	RNA binding protein	0.00334
	Transcription factor	0.00320
	Adapter molecule	0.00296
	Structural protein	0.00259
	Transcription regulatory protein	0.00255

The binding ratio is calculated as the percentage of proteins interacting with proteins containing SH2, SH3 domains. The phosphorylatio ratio is calculated as the percentage of serine residues being phosphorylated.

ISSN: 1471-2164