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Figure 3 | BMC Genomics

Figure 3

From: Overlapping mouse subcongenic strains successfully separate two linked body fat QTL on distal MMU 2

Figure 3

High resolution QTL LOD profile for Total Fat of the 2.3 Mb CI of Fatq2b . (A) Interval mapping and Composite Interval Mapping (CIM) LOD score profile for the HG2D region on Mouse Chromosome 2. (B) Magnification of Fatq2b (173.2 – 175.5 Mb). Median LOD score profiles after 400 replications of CIM. Two step and window sizes representative of all CIM parameter combinations are shown (Additional file 2: Figures S3 and S4) show median LOD scores for all parameter combinations). Genes are shown under the peak, with the direction of the arrows indicating sense of transcription. The horizontal gray line represents LOD threshold of IM value at α = 0.01 of 1000 permutations. (C) Dark red represents all the conserved non-coding sequences (CNS) in the Fatq2b region, orange lines represent intergenic conserved sequences that were analyzed for plausible promoters, transcription factors and gene elements. Light blue lines represent conserved gene elements among mice, humans and dogs. Green lines show the approximate locations of putative miRNA sequences that were identified by BLAST (Positions are an approximation since an 81 bp fragment would be too small to visualize on the scale).

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