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Table 2 Differential expression of immune associated genes at 0, 2, and 8 hours post-LPS exposure of fibroblasts collected at 16 months of age compared to fibroblasts collected at 5 months of age from the same three animals

From: Age dependent changes in the LPS induced transcriptome of bovine dermal fibroblasts occurs without major changes in the methylome

Gene Hour 0 Hour 2 Hour 8
Innate Immune Related Genes  
CCL2 - - 7.3 3.2
CCL20 - - 18.1 10.1
CCL5 - - 10.7 3.4
CD14 5.5 5.7 4.2
IFIH1 - - - - 2.1
IL1A - - 2.3 2.8
IL6 - - 10.5 7.9
IL8 - - 5.8 3.3
MX2 - - - - 33.9
OAS1 - - - - 12.8
OAS2 - - - - 10.6
SAA3 - - - - 5.1
TLR2 - - 4 2.6
TLR4 2.1 - - 2.6
TNF - - 10.4 - -
DNA Methylation Associated Genes  
DNMT1 1.6 1.6 1.6
DNMT3A - - - - - -
DNMT3B - - - - - -
UHRF1 3.4 3.3 3.6
  1. Data obtained by RNA-Seq and presented as fold change between cultures from younger and older animals. Positive values indicate higher expression in 16-month old cultures as compared to cultures from 5-month old animals. All presented values indicate FDR < 0.05 with an average CPM > 1, while - - notes a values with either FDR > 0.05 or an average CPM < 1.