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Table 3 Differentially methylated 3 Kb regions between young and old individuals as identified by MIRA-Seq and gene expression data for annotated genes

From: Age dependent changes in the LPS induced transcriptome of bovine dermal fibroblasts occurs without major changes in the methylome

     RNA-Seq fold difference
Fold difference* Chr Genomic coordinates Gene** Hour 0 Hour 2 Hour 8
4.6 1 72956301-72959300 XXYLT1 1.0 −1.6 −1.0
−5.3 2 25773034-25776033 SP5 1.0 1.0 1.0
3.7 2 70978934-70981933 - - - - - - - -
4.7 2 126997334-127000333 ARID1A 1.0 −1.4 1.0
5 2 88469334-88472333 - - - - - - - -
4.9 3 116651410-116654409 CXCR7 −1.2 −1.6 −1.3
4.9 5 117094706-117097705 - - - - - - - -
4 7 52484546-52487545 - - - - - - - -
−4 8 75361987-75364986 ADRA1A 1.0 1.0 1.1
4.2 8 43784287-43787286 DMRT2 −1.1 −1.3 −1.2
6.1 8 101360987-101363986 PALM2 −1.7 −2.4 −1.9
4.7 9 95637251-95640250 - - - - - - - -
−4.3 11 8944985-8947984 LOC100337252 5.2 −1.6 2.5
3.7 11 95333785-95336784 - - - - - - - -
−3.8 12 80725922-80728921 - - - - - - - -
−6.2 17 62367994-62370993 - - - - - - - -
−5.3 17 62346994-62349993 - - - - - - - -
3.6 19 44563675-44566674 HDAC5 1.1 1.2 −1.5
−4.3 21 65927663-65930662 - - - - - - - -
5.9 23 8944593-8947592 ANKS1A 1.3 −1.2 1.1
  1. *Data obtained by MIRA-Seq and presented as fold difference in read count of methylated regions. Positive fold change indicates higher methylation levels in cultures from younger animals while negative values are higher methylation in cultures from older animals.
  2. **DMRs with an associated gene indicate that some portion of the 3Kb region falls within an annotated gene, while - - indicates DMRs that are intergenic.