Three-dimensional modeling of KBM7 genome architecture.
(a) Three-dimensional structure of the 2 Mb region of chromosome 11 (chr11:1,000,000-3,000,000) which is centered around IGF2-H19 imprinting control region. This structure is inferred from normalized contact counts of KBM7-TM3C-1 data at 40 kb resolution using the Poisson model from Varoquaux et al. . (b) Three-dimensional structure of the KBM7 genome, which is haploid for all chromosomes other than diploid chromosome 8 (8A, 8B) and partially diploid chromosome 15 (15A, 15B) (see Methods for details of the 3D inference). Different colors represent different chromosomes, and white balls represent chromosome ends. Same 3D structure as (b) when confined to (c) only a subset of long chromosomes, (d) only a subset of small chromosomes, (e) two small and two large chromosomes.