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Table 1 Carotenoid-related candidate gene

From: A de novo transcriptome of the noble scallop, Chlamys nobilis, focusing on mining transcripts for carotenoid-based coloration

Name Evidence for potential role in carotenoid deposition Protein ID Reference
ninaD Responsible for carotenoid uptake in Drosophila and mutation leads to carotenoid deficient AAO11676 [12]
SRB type I Involved in the uptake of carotenoids; homologous to ninaD in Drosophila NP_005496 [10]
Cameo2 Involved in selective absorption of lutein BAI66272 [13]
CD36 Homologous to carotenoid-uptake gene Cameo2 and SCRB15 in Bombyx mori NP_000063 [13,14]
Carotenoid binding protein (CBP) Involved in lutein binding and transportation in B. mori BAC01051 [17]
MLN64(STAR3) Orthologue of B. mori CBP NP_001159410 [16]
Crustacyanin CBP in the carapace of crustaceans and binding astaxanthin 1GKA_B [24]
BCDO Lower expression levels lead to the retention of carotenoids and a yellow skin phenotype ACA05952 [18,19]
BCMO Lower activity leads to hypercarotenemia in human being NP_059125 [20]
NPC1L1 Involved in intocopherol intestinal absorption using Caco-2 cells and in situ perfusions in rats. Lower expression levels inhibit the uptake of several carotenoids in Caco-2 cells. NP_037521 [21]
GST Binding carotenoid in the mammalian retina AAH10915 [23]
ABCG5 A genetic variant in ABCG5 associate with plasma lutein concentration NP_071881 [22]
RXR/RAR Form heterodimers of RXR-RAR and regulate retinoid-responsive elements RXR:NP_002948 [26]
ISX Gatekeeper that controls intestinal β, β-carotene absorption NP_082113 [25]