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Table 1 Structural variants associated with coding sequences

From: Complete genome sequence of the Clostridium difficile laboratory strain 630Δerm reveals differences from strain 630, including translocation of the mobile element CTn5

AM183055 start AM183055 end 630Δ erm start 630Δ erm end Type Description Region Gene name Function Details
84143   89438   Substitution C > T CD630_00580 tuf1 Elongation factor EFTu/EF1A Synonymous
84227   89522   substitution C > T CD630_00580 tuf1 Elongation factor EFTu/EF1A Synonymous
103225   108520   substitution G > T CD630_00730 rplC 50S ribosomal protein L3 Synonymous
610336   615631   substitution G > A CD630_05140 cwpV Cell surface protein Val > Ile
610480   615775   substitution C > T CD630_05140 cwpV Cell surface protein Synonymous
610563 610564 615859 615861 insertion 610563_610564ins CD630_05140 cwpV Cell surface protein In frame Ala insertion
610570   615868   substitution A > G CD630_05140 cwpV Cell surface protein Ile > Val
610638   615936   substitution C > T CD630_05140 cwpV Cell surface protein Synonymous
610752   616050   substitution G > A CD630_05140 cwpV Cell surface protein Synonymous
610840   616138   substitution C > T CD630_05140 cwpV Cell surface protein Synonymous
610875   616173   substitution C > T CD630_05140 cwpV Cell surface protein Synonymous
755776 755800 760995 760996 deletion 755776_755800del CD630_06320   Conserved hypothetical protein In frame 8aa deletion in repeat region
1000995   1006274   substitution A > G CD630_08260   Putative ferric-uptake regulator Thr > Ala
1391850   1397129   substitution T > C CD630_11900   Putative acyl-CoA N-acyltransferase Phe > Leu
1413060 1413077 1418339 1418354 duplication 1413060_1413077dup CD630_12140 spo0A Stage 0 sporulation protein A 6aa (NVGNIE) duplication
1607458 1607459 1612756   insertion 1607458_1607459insT CD630_13880   Putative transcriptional regulator Restores transcriptional regulator
2044514   2049813   substitution C > G CD630_17670 gapB Glyceraldehyde-3-phosphate dehydrogenase GAPDH Pro > Ala
2137467 2183040 2142764 2142765 deletion 2137467_2183040del CD630_18440   Putative adhesin Translocation of CTn5, CD1844 restored
2209236   2168961   substitution G > A CD630_19070 eutG Ethanolamine iron-dependent Alcohol dehydrogenase Gly > Glu
2924655   2881973   substitution C > T CD630_25320   Aminotransferase, alanine--glyoxylate transaminase Synonymous
3034953   2992271   substitution C > A CD630_26270   Conserved hypothetical protein Gly > Cys
3080703   3038021   substitution C > T CD630_26670 ptsG-BC PTS system, glucose-specific IIBC component Val > Ile
3686534 3686535 3643756 3643756 insertion 3686534_3686535insA CD630_31561   Conserved hypothetical protein Restores conserved hypothetical protein
3967522 3967523 3924743 3970315 insertion 3967522_3967523insAM180355:g.2137467_2183040 CD630_33930 rumA 23S rRNA (uracil-5-)-methyltransferase Translocation of CTn5; fuses rumA (CD3393) to CD1844A
4166495   4169292   substitution G > A CD630_35650   Transcriptional regulator, GntR family Ala > Val
12347 12348 12348 17642 insertion 12347_12348ins multiple    rRNA/tRNA cluster
2317627 2320033 2277358 2277359 deletion 2317633_2320041del multiple    Loss of erythromycin resistance (Δerm)