Methodology workflow for detecting integromics modules.
A. Construction of the miRNA-mRNA multi-layer regulatory network based on interaction databases and hypergeometric distribution (in case of miRNA-miRNA relations). B. Two adapted weighting schemes were employed to integrate the mRNA/miRNA expression information onto the corresponding network layer so as to create the integromics network. C. The integromics network was the input to the DMSP module-detecting algorithm and statistically significant modules (P-value < 0.05) were identified based on a permutation strategy on the expression data.