Integromics network meta-analysis on cardiac aging offers robust multi-layer modular signatures and reveals micronome synergism

Dimitrakopoulou, Konstantina; Vrahatis, Aristidis G; Bezerianos, Anastasios

doi:10.1186/s12864-015-1256-3

Table 1 miRNA synergism results relative to consensus modules

From: Integromics network meta-analysis on cardiac aging offers robust multi-layer modular signatures and reveals micronome synergism

miRNA A	miRNA B	Borda rank	Disease A	Disease B	Literature A	Literature B
miR-125a-5p	miR-351	5	Various cancer types			[26]
miR-200c	miR-429	10	Various cancer types	Various cancer types	[27,28]	[28]
miR-125b-5p	miR-351	112	Cardiac hypertrophy		[29]	[26]
miR-15b	miR-195	174	Cardiac hypertrophy	Cardiac hypertrophy/heart failure	[6]
miR-148a	miR-152	194	Various diseases	Various diseases		[30,31]
miR-200b	miR-200c	199	Various cancer types	Various cancer types	[28]	[28]
miR-132	miR-190b	221	Various diseases		[32]
miR-190b	miR-465a-5p	261
miR-190b	miR-692	309
miR-107	miR-15b	327	Cardiac hypertrophy	Cardiac hypertrophy		[6]
miR-152	miR-195	342	Various diseases	Cardiac hypertrophy/heart failure	[30,31]
miR-148b	miR-152	353	Various diseases	Various diseases		[30,31]
miR-132	miR-429	371	Various diseases	Various cancer types		[28]
miR-130b	miR-301a	372	Various cancer types			[33]
miR-135a	miR-135b	395	Various cancer types	Various cancer types	[34,35]
miR-101a	miR-101b	396	Various cancer types
miR-147	miR-148a	397	Various cancer types	Various diseases	[35]
miR-125a-5p	miR-125b-5p	400	Various cancer types	Cardiac hypertrophy		[29]
miR-133a	miR-133b	401	Cardiac hypertrophy/cardiomyopathy/myocardial infarction	Myocardial infarction	[36,37]	[36,37]
miR-103	miR-107	407	Cardiac hypertrophy	Cardiac hypertrophy
miR-141	miR-200a	408	Various cancer types	Various cancer types	[38]	[28]
miR-147	miR-148b	410	Various cancer types	Various diseases
miR-200a	miR-200b	412	Various cancer types	Various cancer types	[28]	[28]
miR-141	miR-200b	413	Various cancer types	Various cancer types	[38]	[28]
miR-148a	miR-148b	415	Various diseases	Various diseases
miR-200b	miR-204	427	Various cancer types	Various cancer types	[28]
miR-141	miR-200c	464	Various cancer types	Various cancer types	[38]	[28]
miR-26a	miR-26b	465	Cardiac hypertrophy	Cardiac hypertrophy		[39]
miR-23a	miR-23b	493	Cardiac hypertrophy	Cardiac hypertrophy
miR-135a	miR-200a	494	Various cancer types	Various cancer types	[34,35]	[28]
miR-204	miR-211	537	Various cancer types	Various cancer types

miRNA synergism results for the consensus modules according to Borda voting scheme. Each line reports the Borda rank of each miRNA pair identified in the final consensus modules, disease-related information of the human orthologs as recorded in miR2Disease database (if found only cardiac pathophysiology related terms are reported) and evidence related to aging or cardiac pathophysiology provided by recent literature. We denote that in many cases each member of the reported miRNA pair can participate in a different module. Bold miRNAs are age-dependent based on linear regression analysis.

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ISSN: 1471-2164

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