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Table 1 miRNA synergism results relative to consensus modules

From: Integromics network meta-analysis on cardiac aging offers robust multi-layer modular signatures and reveals micronome synergism

miRNA A miRNA B Borda rank Disease A Disease B Literature A Literature B
miR-125a-5p miR-351 5 Various cancer types    [26]
miR-200c miR-429 10 Various cancer types Various cancer types [27,28] [28]
miR-125b-5p miR-351 112 Cardiac hypertrophy   [29] [26]
miR-15b miR-195 174 Cardiac hypertrophy Cardiac hypertrophy/heart failure [6]  
miR-148a miR-152 194 Various diseases Various diseases   [30,31]
miR-200b miR-200c 199 Various cancer types Various cancer types [28] [28]
miR-132 miR-190b 221 Various diseases   [32]  
miR-190b miR-465a-5p 261     
miR-190b miR-692 309     
miR-107 miR-15b 327 Cardiac hypertrophy Cardiac hypertrophy   [6]
miR-152 miR-195 342 Various diseases Cardiac hypertrophy/heart failure [30,31]  
miR-148b miR-152 353 Various diseases Various diseases   [30,31]
miR-132 miR-429 371 Various diseases Various cancer types   [28]
miR-130b miR-301a 372 Various cancer types    [33]
miR-135a miR-135b 395 Various cancer types Various cancer types [34,35]  
miR-101a miR-101b 396 Various cancer types    
miR-147 miR-148a 397 Various cancer types Various diseases [35]  
miR-125a-5p miR-125b-5p 400 Various cancer types Cardiac hypertrophy   [29]
miR-133a miR-133b 401 Cardiac hypertrophy/cardiomyopathy/myocardial infarction Myocardial infarction [36,37] [36,37]
miR-103 miR-107 407 Cardiac hypertrophy Cardiac hypertrophy   
miR-141 miR-200a 408 Various cancer types Various cancer types [38] [28]
miR-147 miR-148b 410 Various cancer types Various diseases   
miR-200a miR-200b 412 Various cancer types Various cancer types [28] [28]
miR-141 miR-200b 413 Various cancer types Various cancer types [38] [28]
miR-148a miR-148b 415 Various diseases Various diseases   
miR-200b miR-204 427 Various cancer types Various cancer types [28]  
miR-141 miR-200c 464 Various cancer types Various cancer types [38] [28]
miR-26a miR-26b 465 Cardiac hypertrophy Cardiac hypertrophy   [39]
miR-23a miR-23b 493 Cardiac hypertrophy Cardiac hypertrophy   
miR-135a miR-200a 494 Various cancer types Various cancer types [34,35] [28]
miR-204 miR-211 537 Various cancer types Various cancer types   
  1. miRNA synergism results for the consensus modules according to Borda voting scheme. Each line reports the Borda rank of each miRNA pair identified in the final consensus modules, disease-related information of the human orthologs as recorded in miR2Disease database (if found only cardiac pathophysiology related terms are reported) and evidence related to aging or cardiac pathophysiology provided by recent literature. We denote that in many cases each member of the reported miRNA pair can participate in a different module. Bold miRNAs are age-dependent based on linear regression analysis.
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