Skip to main content

Table 2 COG groups with the highest DDs

From: Comparing Mycobacterium tuberculosis genomes using genome topology networks

COG ID

Annotation

DD/Str.

Paralog/Str.

DD/Paralog

COG2963

Transposase and inactivated derivatives

24

14

1.71

COG2801

Transposase and inactivated derivatives

28

18

1.56

COG3547

Transposase and inactivated derivatives

6

6

1.00

COG3328

Transposase and inactivated derivatives

5

9

0.56

COG5651

PPE-repeat proteins

31

62

0.50

COG2114

Adenylate cyclase, family 3 (some proteins contain HAMP domain)

6

12

0.50

COG0515

Serine/threonine protein kinase

5

11

0.45

COG1680

Beta-lactamase class C and other penicillin-binding proteins

5

11

0.45

COG0277

FAD/FMN-containing dehydrogenases

6

14

0.43

COG2409

Predicted drug exporters of the RND superfamily

6

14

0.43

COG3321

Polyketide synthase modules and related proteins

8

19

0.42

COG1024

Enoyl-CoA hydratase/carnitine racemase

9

23

0.39

COG0657

Esterase/lipase

5

13

0.38

COG0596

Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

12

34

0.35

COG3315

O-Methyltransferase involved in polyketide biosynthesis

6

17

0.35

COG1309

Transcriptional regulator

17

49

0.35

COG0318

Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

11

32

0.34

COG1960

Acyl-CoA dehydrogenases

12

35

0.34

COG2141

Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases

6

19

0.32

COG2124

Cytochrome P450

6

20

0.30

COG0477

Permeases of the major facilitator superfamily

8

27

0.30

COG1848

Predicted nucleic acid-binding protein, contains PIN domain

5

19

0.26

COG0500

SAM-dependent methyltransferases

9

37

0.24

COG1028

Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

9

41

0.22

  1. DD/Str.: The averages of different degrees. The COG group’s average DDs higher than five are shown; Paralog/Str.: The average paralog number (rounded) of thirteen M. tuberculosis strains.