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Table 2 COG groups with the highest DDs

From: Comparing Mycobacterium tuberculosis genomes using genome topology networks

COG ID Annotation DD/Str. Paralog/Str. DD/Paralog
COG2963 Transposase and inactivated derivatives 24 14 1.71
COG2801 Transposase and inactivated derivatives 28 18 1.56
COG3547 Transposase and inactivated derivatives 6 6 1.00
COG3328 Transposase and inactivated derivatives 5 9 0.56
COG5651 PPE-repeat proteins 31 62 0.50
COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) 6 12 0.50
COG0515 Serine/threonine protein kinase 5 11 0.45
COG1680 Beta-lactamase class C and other penicillin-binding proteins 5 11 0.45
COG0277 FAD/FMN-containing dehydrogenases 6 14 0.43
COG2409 Predicted drug exporters of the RND superfamily 6 14 0.43
COG3321 Polyketide synthase modules and related proteins 8 19 0.42
COG1024 Enoyl-CoA hydratase/carnitine racemase 9 23 0.39
COG0657 Esterase/lipase 5 13 0.38
COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) 12 34 0.35
COG3315 O-Methyltransferase involved in polyketide biosynthesis 6 17 0.35
COG1309 Transcriptional regulator 17 49 0.35
COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II 11 32 0.34
COG1960 Acyl-CoA dehydrogenases 12 35 0.34
COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases 6 19 0.32
COG2124 Cytochrome P450 6 20 0.30
COG0477 Permeases of the major facilitator superfamily 8 27 0.30
COG1848 Predicted nucleic acid-binding protein, contains PIN domain 5 19 0.26
COG0500 SAM-dependent methyltransferases 9 37 0.24
COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) 9 41 0.22
  1. DD/Str.: The averages of different degrees. The COG group’s average DDs higher than five are shown; Paralog/Str.: The average paralog number (rounded) of thirteen M. tuberculosis strains.