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Table 3 Pathway (KEGG) enrichment analysis of lost genes from three strains

From: Comparing Mycobacterium tuberculosis genomes using genome topology networks

Strain
( M. tuberculosis )
Total Lost
(vs. H37Rv)
Hits Pathway P-value
RGTB327 599 17 mtu00230:Purine metabolism 0.00
12 mtu00240:Pyrimidine metabolism 0.01
10 mtu00361:gamma-Hexachlorocyclohexane degradation 0.01
13 mtu00624:1- and 2-Methylnaphthalene degradation 0.00
16 mtu00632:Benzoate degradation via CoA ligation 0.01
16 mtu00903:Limonene and pinene degradation 0.01
5 mtu01053:Biosynthesis of siderophore group nonribosomal peptides 0.01
16 mtu02010:ABC transporters 0.00
RGTB423 685 15 mtu00071:Fatty acid metabolism 0.00
16 mtu00230:Purine metabolism 0.01
10 mtu00250:Alanine, aspartate and glutamate metabolism 0.00
8 mtu00260:Glycine, serine and threonine metabolism 0.04
18 mtu00280:Valine, leucine and isoleucine degradation 0.00
19 mtu00281:Geraniol degradation 0.00
13 mtu00330:Arginine and proline metabolism 0.00
7 mtu00360:Phenylalanine metabolism 0.03
15 mtu00380:Tryptophan metabolism 0.00
10 mtu00410:beta-Alanine metabolism 0.04
6 mtu00480:Glutathione metabolism 0.03
13 mtu00624:1- and 2-Methylnaphthalene degradation 0.01
16 mtu00632:Benzoate degradation via CoA ligation 0.03
19 mtu00640:Propanoate metabolism 0.00
16 mtu00903:Limonene and pinene degradation 0.03
8 mtu00910:Nitrogen metabolism 0.01
9 mtu00930:Caprolactam degradation 0.04
6 mtu01053:Biosynthesis of siderophore group nonribosomal peptides 0.00
16 mtu02020:Two-component system 0.00
7 mtu03030:DNA replication 0.01
CDC1551 166 4 mtu00310:Lysine degradation 0.01
2 mtu00540:Lipopolysaccharide biosynthesis 0.03
4 mtu00650:Butanoate metabolism 0.02
  1. Pathway: KEGG pathways are enriched in lost genes. Shared pathways between RGTB327 and RGTB423 are shown in bold.