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Figure 5 | BMC Genomics

Figure 5

From: Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer’s disease donor as a model for investigating AD-associated gene regulatory networks

Figure 5

Treatment of AD neuronal cells with the γ-secretase-inhibitor compound E (CE). Western blot analysis was used to monitor the expression of phosphorylated tau (p-tau), non-phosphorylated tau, GSK3α/β and phosphorylated GSK3β in AD-iPS5 neurons (INC5) and AD-iPS26B neurons (INC26B). The samples were derived from one well of a single neuronal differentiation. The parental fibroblast cells (NFH-46) were included as control in addition to the positive control (PC) for p-tau represented by lysate from neuroblastoma. β-ACTIN and GAPDH and coomassie blue staining were used to confirm similar protein loading across samples.

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BMC Genomics

ISSN: 1471-2164

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