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Figure 6 | BMC Genomics

Figure 6

From: miR-503 represses human cell proliferation and directly targets the oncogene DDHD2 by non-canonical target pairing

Figure 6

miR-503 involvement in breast cancer. (A) Low miR-503 expression correlates with a lower survival probability in ER+ breast cancer patients (p = 8.56e-06). Kaplan-Meier survival curves for patients with ER+ breast cancer expressing different levels of miR-503 were calculated using the MIRUMIR tool. Number of patients: n = 37. (B) DDHD2 is frequently amplified in breast cancer. The bars are the frequency of DDHD2 copy number alterations in the different types of cancer indicated on the X-axis. The frequency of patients with DDHD2 amplification was calculated using the cBio portal. Yellow: Deletion; Orange: Amplification. n = 1044. (C) Patients with copy number alterations in DDHD2 (purple line) have a lower survival probably than those without amplifications in DDHD2 (green line) (p = 0.027). Kaplan-Meier survival curves were was calculated using the cBio portal. n = 888.

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