Figure 3
From: Factors to preserve CpG-rich sequences in methylated CpG islands
Base substitution rate in sperm methylated CGIs with CpG → TpG/CpA < 0.03825. A, B, C, D, E, and F show the average CpG → TpG/CpA, TpG/CpA → CpG, CpG → GpG/ApG/CpC/CpT, GpG/ApG/CpC/CpT → CpG, A/T → G/C, and G/C → A/T substitution rates in CGIs with a CpG → TpG/CpA substitution rate of <0.03825 and SPM-HM, respectively. The prefixes of H1-LM- and H1-HM- show low and high methylation of CGIs in H1 cells, respectively. Coding- and non-coding- indicate CGIs that associate with protein-coding and non-coding genes, respectively. Molaro_pooled, BCMsample25784, and BCMsample25783 describe separate human sperm samples. SPM-LM denotes CGIs with a low methylation of ≤20% in sperm cells. SPM-HM shows CGIs with a high methylation of ≥80% in sperm cells. Error bars represent standard errors. CpG → TpG/CpA < 0.03825 shows a CpG → TpG/CpA substitution rate of <0.03825.