Figure 2
Colon cis- eQTL that are also associated with colonic diseases. The box plots depict the relationship between SNPs associated with (A) IBD (i.e. CD and/or UC) or (B) CRC from the NHGRI GWAS catalog and their target gene’s expression. The x-axes correspond to the SNP genotypes, and the y-axes represent the log2-normalized gene expression values. The median gene expression level for each genotype is indicated by a horizontal line with the boxes covering 25th and 75th percentiles and the whiskers extending to 1.5 times the interquartile range. Points outside the whiskers are plotted as outliers. For each target gene, the disease-associated SNP was selected for the box plot even if it is not the most significant cis-eQTL (but must be in r2 ≥ 0.8 with it).