Skip to main content

Table 2 Colon cis -eQTL that are associated with Crohn’s disease (CD) and/or ulcerative colitis (UC) as well as colorectal cancer (CRC)

From: Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci

 

SNP/gene

Proxy SNP* (r 2 )

eQTL p-value

Both CD and UC

rs1363907/ERAP2

 

1.4 × 10−8

 

rs6545800/ADCY3

rs2384061 (r2 = 0.82)

1.3 × 10−7

 

rs4077515/INPP5E

rs4266763 (r2 = 0.95)

4.7 × 10−6

 

rs9858542/UBA7

rs10640 (r2 = 0.92)

8.7 × 10−6

CD only

rs2549794/ERAP2

 

1.5 × 10−8

UC only

rs9847710/SFMBT1

 

8.3 × 10−6

 

rs6781710/NXPE1 & REX02

rs661946 (r2 = 0.94)

8.7 × 10−7

CRC

rs3802842/COLCA2

 

1.1 × 10−6

  1. *SNPs in LD (r2 ≥ 0.8) with disease-associated GWAS SNPs from the NHGRI catalog. r2 corresponds to the correlation between the proxy SNP and the GWAS SNP, calculated based on the 48 African American samples in the colon dataset.
Back to article page

BMC Genomics

ISSN: 1471-2164

Contact us