Redundancy amongst interactions affecting HLA-G expression in the pre-frontal cortex. (a) Linkage disequilibrium (r2) amongst cis-SNPs (top left), amongst trans-SNPs (bottom right) and between Bonferroni significant cis-trans interacting SNPs (bottom left). The interactions are denoted as positive or negative depending on the directionality of the interaction coefficient. (b) Schematic showing the relative proximity of SNPs involved in interactions. By comparing linkage disequilibrium amongst cis-SNPs, amongst trans-SNPS and the direction of the interaction effect, the 6 interactions affecting. HLA-G collapse into 3 three groups of non-redundant interactions, (Group 1: rs10947091-rs2524089, rs10947091-rs2243868, rs13201769-rs2524089, rs13201769-rs2243868; Group 2: rs915664-rs3094212; Group 3: rs3869070-3093998).