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Table 1 Bonferroni significant cis-trans interactions in the liver, pre-frontal cortex and the cerebellum

From: Genome-wide epistatic expression quantitative trait loci discovery in four human tissues reveals the importance of local chromosomal interactions governing gene expression

Tissue

Cis-SNP

Cis position

Trans SNP

Trans position

Transcript

Interaction p-value

Effect size

Liver

rs3129045

6:29652576

rs7761068

6:31333939

HLA-G

9.35 × 10−7

54.67

 

rs2747442

6:29653186

rs7761068

6:31333939

HLA-G

2.22 × 10−5

47.63

 

rs2747436

6:29651935

rs7761068

6:31333939

HLA-G

2.54 × 10−5

45.42

Pre-frontal cortex

rs9267873

6:32199352

rs2247056

6:31265490

HLA-DRB5

2.19 × 10−8

83.34

 

rs9267873

6:32199352

rs6457374

6:31272261

HLA-DRB5

2.74 × 10−8

83.10

 

rs507778

6:32209861

rs6457374

6:31272261

HLA-DRB5

1.57 × 10−7

−80.99

 

rs507778

6:32209861

rs2247056

6:31265490

HLA-DRB5

2.32 × 10−7

−79.75

 

rs2072633

6:31919578

rs3093998

6:31485174

HLA-DRB5

1.05 × 10−7

74.74

 

rs592229

6:31930441

rs3093998

6:31485174

HLA-DRB5

2.09 × 10−7

72.20

 

rs805262

6:31628733

rs2247056

6:31265490

HLA-DRB5

2.34 × 10−6

−70.73

 

rs805262

6:31628733

rs6457374

6:31272261

HLA-DRB5

3.10 × 10−6

−70.46

 

rs2858331

6:32681277

rs3093998

6:31485174

HLA-DRB5

3.24 × 10−6

−67.31

 

rs915664

6:30794617

rs3094212

6:31085770

HLA-G

6.56 × 10−7

63.74

 

rs13201769

6:30756066

rs2524089

6:31266522

HLA-G

7.48 x 10−7

−60.37

 

rs13201769

6:30756066

rs2243868

6:31261276

HLA-G

8.01 × 10−7

−60.38

 

rs10947091

6:30747216

rs2524089

6:31266522

HLA-G

9.66 × 10−7

−60.94

 

rs10947091

6:30747216

rs2243868

6:31261276

HLA-G

1.05 × 10−6

−60.91

 

rs3869070

6:30023868

rs3093998

6:31485714

HLA-G

1.86 × 10−6

66.69

Cerebellum

rs11744596

5:68519291

rs13168712

5:70679626

LOC100506658

1.52 × 10−6

−56.61

 

rs2932777

5:68525027

rs13168712

5:70679626

LOC100506658

1.52 × 10−6

−56.61

  1. Table shows the interacting cis and trans SNP identifiers, positions and two-locus p-values for the Bonferroni significant interactions in three of the four tissues studied. Groups of dependent SNPs resulting from linkage disequilibrium amongst groups of cis-SNPs and groups of trans-SNPs are demarcated by a black horizontal line.