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Table 2 Epistatic interactions that map to HiC interactions

From: Genome-wide epistatic expression quantitative trait loci discovery in four human tissues reveals the importance of local chromosomal interactions governing gene expression

Tissue

HiC interactions

 

Epistatic

Non-epistatic

Odds ratio

P-value

Liver

14/34

913/9772

6.79

< 0.0001

Pre-Frontal Cortex

118/321

13450/125873

4.86

< 0.0001

Cerebellum

39/105

6758/77511

6.19

< 0.0001

Visual Cortex

19/66

3422/40882

4.43

< 0.0001

  1. SNP pairs that map to HiC interactions (spatially proximate regions of the genome) are given as the proportion of epistatic interactions that map to at least one HiC interaction and the proportion of non-epistatic SNP pairs tested that map to at least one HiC interaction. The odds ratio that a pair of epistatic SNPs also maps to a HiC physical interaction is given for each tissue. Significance is assessed using a chi-squared test for goodness of fit.