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Figure 1 | BMC Genomics

Figure 1

From: Proteome mapping of epidermal growth factor induced hepatocellular carcinomas identifies novel cell metabolism targets and mitogen activated protein kinase signalling events

Figure 1

Liver proteome mapping of healthy non-transgenic control and EGF transgenic mice. (A) Histopathology of a well-organized normal liver tissue of a non-transgenic control (image magnification 25-fold). (B) Histopathology of completely disorganized tissue of advanced HCC showing multilayered hepatocytic trabeculae besides solid areas, peliosis-like intratumourous vasectasias and focal necroses (light red) (image magnification 25-fold). (C) Zoom-in 2D gel image of healthy non-transgenic control liver extracts in the pH range of 5–8. (D) Zoom-in 2D gel image of healthy non-transgenic control liver extracts in the pH range of 7–10.Panel E to G depict examples of zoom-in 2D gels of regulated proteins. (E) Spot 1: glycine N-methyltransferase, identified in control samples only; Spot 2: peroxiredoxin 6, up-regulated in tumour samples; Spot 3: peroxiredoxin 6, down-regulated in tumour samples; Spot 4: lysophospholipase 1, down-regulated in tumour samples; Spot 5: hypothetical protein LOC68347, down-regulated in tumour samples; Spot 6: glutathione peroxidase 1, down-regulated in tumour samples. (F) Examples of up-regulated mouse liver proteins: fibrinogen β (I), vimentin (II), Cu/Zn superoxide dismutase (III), and apolipoprotein E (IV). (G) Examples of down-regulated mouse liver proteins: arginase 1 (I), Dhdh protein (II), glutathione peroxidase 1 (III) and predicted: agmatine ureohydrolase (IV).

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BMC Genomics

ISSN: 1471-2164

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