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Figure 9 | BMC Genomics

Figure 9

From: Proteome mapping of epidermal growth factor induced hepatocellular carcinomas identifies novel cell metabolism targets and mitogen activated protein kinase signalling events

Figure 9

Pathways mapping of fussed network proteins. Cytoscape 3.0.2 with plugins (see Methods section) are used to generate functionally grouped network of pathways. Grouping of significant pathway terms (p ≤ 0.05) were based on kappa score threshold of 0.4, initial group size of 2 and sharing group percentage of 50. The pathway network consisted of 35 significantly and 7 non-significantly regulated proteins involved in distinct pathways which are colour-coded. Note, the two individual terms are grey-coloured. Up and down-regulated proteins are coded as orange and green small discs, respectively. Up- and down-regulated as well as non-significantly regulated proteins and connecting proteins of the network are given as orange, green, yellow and blue coloured discs, respectively. The network depicts protein-protein interactions in liver tumours of EGFR transgenic mice and their relation to various pathways under the influence of EGFR signalling. EGFR is highlighted as blue triangle in this network.

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BMC Genomics

ISSN: 1471-2164

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