Figure 4

Comparison of amino acid sequence of Sjda with DNaseII molecules from various species. A. Phylogenetic tree constructed with amino acid sequences of Sjda and 10 DNase II molecules from other species. The protein name includes the species name and NCBI protein bank ID. A scale of 0.2 is shown below the tree. The frequency for each sequence is shown in brackets before the name. B. Amino acid sequence alignments of Sjda and S. mansoni, human, mouse and C. elegans DNase II homologues. The catalytic domains are enclosed inboxes. * indicates conserved cysteine residues. Residues that are present in all sequences are highlighted with dark-grey shading. Residues that are conserved in at least three sequences are highlighted in grey. The dots indicate missing residues.