Skip to main content

Table 4 Validation of top differentially expressed genes in PTC, FTC and ATC with two independent datasets

From: Genome-wide expression analysis suggests a crucial role of dysregulation of matrix metalloproteinases pathway in undifferentiated thyroid carcinoma

Subtype

Gene name

Set 1-Validated

Set 2-Validated

FTC

ZCCHC12

yes

yes

 

PRR15

yes

yes

 

CA12

yes

yes

 

TENM1

yes

no

 

ARHGAP36

no

no

FTC

ADH1B

yes

yes

 

DCN

yes

yes

 

CCL21

yes

yes

 

CHRDL1

yes

yes

 

DPT

yes

yes

PTC

GABRB2

yes

yes

 

HMGA2

yes

yes

 

PRR15

yes

yes

 

CHI3L1

yes

yes

 

ZCCHC12

yes

yes

PTC

PKHD1L1

yes

yes

 

TFF3

yes

yes

 

TPO

yes

yes

 

DIO1

yes

yes

 

ADH1B1

yes

yes

ATC

POSTN

yes

yes

 

MMP1

yes

yes

 

SPP1

yes

yes

 

TFPI2

yes

yes

 

VCAN

yes

yes

ATC

DIO1

yes

yes

 

TSHR

yes

yes

 

TG

yes

yes

 

SLC26A7

yes

yes

 

TPO

yes

yes

  1. For this analyisis the 5 top overexpressed and underexpressed genes of our datasets was tested against two independent genome-wide gene expression databases (available in Additional file 4). The first column shows over/under-expression of each gene within our set; second column shows the gene names. Gene validation status (cols. 3 and 4) shows that 27 out of 30 relationships were consistent with our original analysis.