The genome of the basal agaricomycete Xanthophyllomyces dendrorhous provides insights into the organization of its acetyl-CoA derived pathways and the evolution of Agaricomycotina

Table 3 Genes of cytoplasmic (top) and mitochondrial (bottom) fatty acid biosynthesis to linoleic acid in Xanthophyllomyces dendrorhous

Numbering*	Gene name or KEGG EC	Enzyme	Gene ids *X. dendrorhous*	Comparison to other fungal genes**
1	ACC1	Acetyl CoA carboxylase	XDEN_00697	60% Cr.n.; 61% Rh.t.
2	ACP1	Acyl carrier protein	XDEN_03956	64% Cr. n.; 57% Rh. t.
3	FAS2	Fatty acid synthase complex subunit alpha	XDEN_04041	67% Cr.n.; 65% Rh.t.
4	FAS1	Fatty acid synthase complex subunit beta	XDEN_04566	64% Cr.n.; 50% M.c.
5	Elo1	Fatty acid elongase	XDEN_05837	61% Rh.t.; 60% Cr.n.
6	D9DES	Delta 9 fatty acid desaturase	XDEN_04179	68% Cr.n. ; 59% Rh.t.
7	D12DES	Delta 12 fatty acid desaturase	XDEN_05333	59% Cr.n.; 54% Rh.t.
7	D12DES	Delta 12 fatty acid desaturase	XDEN_00895	54% Cr.n.; 48% Rh.t.
8	MCT1	Acetyl CoA acyltransferase 2	XDEN_05455	63% Cr.n.; 62% Rh.t.
9	OAR1	ketoacyl reductase	XDEN_04398	42% C.n.; 43% S.c.
10	MFE2p	Enoyl-CoA hydratase	XDEN_02337	58% Rh.t.; 54% Cr.n.
11	1.1.1.35	3-hydroxyacyl CoA dehydrogenase	XDEN_01855	72% Cr.n.; 71% Rh.t.
12	3.1.2.22	Palmitoyl thioesterase	XDEN_03361	42% Cr.n.

*number of enzyme refers to reactions in Figure 4 (fatty acid synthesis);
**identity to Rh.t. Rhodosporidium toruloides, Cr.n. Cryptococcus neoformans, M.c. Mucor circinelloides, C.g. Candida glabrata, S.c. Saccharomyces cerevisiae.
Enzymes/Genes numbering 1 to 7 from the cytoplasmic pathway, numbers 8 to 9 from the mitochondrial pathway.

ISSN: 1471-2164