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Table 1 Top 10 age-group associated CpG sites from the regression model

From: Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression

ProbeID

Gene

betareg estimate

betareg p-value

Δβ

Wilcoxon p-value

cg16867657

ELOVL2

1.023

6.38E-66

0.243

1.53E-10

cg16762684

MBP

-1.486

4.74E-64

-0.168

1.53E-10

cg11344352

ERCC1

-1.202

9.15E-63

-0.153

1.53E-10

cg17110586

na

0.895

1.46E-59

0.200

1.53E-10

cg04875128

OTUD7A

1.514

7.2E-58

0.279

1.53E-10

cg08262002

LDB2

-0.710

2.72E-55

-0.197

1.53E-10

cg18618815

COL1A1

-0.941

1.78E-52

-0.225

1.53E-10

cg00748589

na

0.864

1.36E-51

0.179

1.53E-10

cg15416179

MAP2K3

-1.131

2.38E-51

-0.187

1.53E-10

cg12065799

RRAGC

-0.823

8.15E-51

-0.088

1.53E-10

cg23479922

MARCH11

0.940

4.07E-49

0.263

1.53E-10

cg07544187

CILP2

1.541

2.35E-48

0.252

1.53E-10

cg09038267

C10orf26

1.227

1.48E-47

0.150

1.53E-10

cg13033938

IP6K1

-0.699

7.54E-47

-0.061

1.53E-10

cg19283806

CCDC102B

-1.253

9.82E-47

-0.267

1.53E-10

cg07547549

SLC12A5

0.900

5.02E-46

0.245

1.53E-10

cg01949403

APOL3

0.807

7.53E-46

0.111

1.53E-10

cg01243823

NOD2

-1.280

7.9E-46

-0.232

1.53E-10

cg22242842

na

-0.952

1.99E-44

-0.206

1.53E-10

cg06007201

FAM38A

-0.932

5.65E-44

-0.156

1.53E-10

  1. CpG sites with most significant association to age group in the beta regression models (betareg). To clarify, Δβ refers to difference in the median of DNA methylation values between nonagenarians and young controls (difference in β-value), whereas betareg estimate refers to the estimate obtained from a regression model termed beta regression. Thus the absolute value of betareg estimate and the absolute value of Δβ for a given CpG site are not directly comparable, only the signs of the values are.