Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression

BMC Genomics

Table 4 Hypermethylation-specific GO process terms in nonagenarians

GO term	Description	P-value	FDR q-value	Rank (out of 265)
GO:0048598	Embryonic morphogenesis	1.25E-22	8.85E-20	17
GO:0048729	Tissue morphogenesis	2.99E-19	1.64E-16	22
GO:0002009	Morphogenesis of an epithelium	6.94E-18	3.22E-15	26
GO:0001763	Morphogenesis of a branching structure	1.84E-17	7.65E-15	29
GO:0048754	Branching morphogenesis of an epithelial tube	1.26E-15	3.09E-13	49
GO:0048562	Embryonic organ morphogenesis	6.12E-14	1.1E-11	67
GO:0009887	Organ morphogenesis	1.13E-13	1.92E-11	71
GO:0035107	Appendage morphogenesis	2.17E-12	2.85E-10	92
GO:0035108	Limb morphogenesis	2.17E-12	2.82E-10	93
GO:0030326	Embryonic limb morphogenesis	7.07E-12	8.7E-10	98
GO:0035113	Embryonic appendage morphogenesis	7.07E-12	8.61E-10	99
GO:0048704	Embryonic skeletal system morphogenesis	2.25E-11	2.56E-9	106
GO:0048705	Skeletal system morphogenesis	1.04E-10	1.11E-8	113
GO:0048732	Gland development	2.37E-10	2.3E-8	124

This table includes only the hypermethylation-specific GO process terms that form a common cluster, associated with development and morphogenesis. The presented p-values are unadjusted and the threshold for significance is 4.15e-6 (Bonferroni). The rank denotes the placement of a given GO term in the list of all significant GO terms. For all statistically significant GO process terms, see Additional file 5.

ISSN: 1471-2164