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Table 5 Hypermethylation-specific GO process terms in nonagenarians

From: Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression

GO term Description P-value FDR q-value Rank (out of 265)
GO:0045935 Positive regulation of nucleobase-containing compound metabolic process 7.07E-17 2.37E-14 36
GO:0051173 Positive regulation of nitrogen compound metabolic process 1.06E-16 3.44E-14 37
GO:0031328 Positive regulation of cellular biosynthetic process 2.74E-16 8.47E-14 39
GO:0009891 Positive regulation of biosynthetic process 3.61E-16 1.06E-13 41
GO:0045893 Positive regulation of transcription, DNA-templated 5.05E-16 1.35E-13 45
GO:0019219 Regulation of nucleobase-containing compound metabolic process 7.72E-16 2.02E-13 46
GO:0010628 Positive regulation of gene expression 1.11E-15 2.78E-13 48
GO:0006357 Regulation of transcription from RNA polymerase II promoter 5.05E-15 1.15E-12 53
GO:0031326 Regulation of cellular biosynthetic process 1.07E-14 2.27E-12 57
GO:0051171 Regulation of nitrogen compound metabolic process 1.28E-14 2.66E-12 58
GO:0009889 Regulation of biosynthetic process 1.45E-14 2.96E-12 59
GO:0051254 Positive regulation of RNA metabolic process 1.8E-14 3.56E-12 61
GO:0006355 Regulation of transcription, DNA-templated 1.98E-14 3.85E-12 62
GO:1902680 Positive regulation of RNA biosynthetic process 2.06E-14 3.93E-12 63
GO:0045944 Positive regulation of transcription from RNA polymerase II promoter 2.94E-14 5.45E-12 65
GO:0010557 Positive regulation of macromolecule biosynthetic process 6.72E-14 1.19E-11 68
GO:0031323 Regulation of cellular metabolic process 1.09E-13 1.87E-11 70
GO:2001141 Regulation of RNA biosynthetic process 1.37E-13 2.29E-11 72
GO:0031325 Positive regulation of cellular metabolic process 2.22E-13 3.57E-11 75
GO:0045934 Negative regulation of nucleobase-containing compound metabolic process 2.8E-13 4.39E-11 77
GO:0031327 Negative regulation of cellular biosynthetic process 3.75E-13 5.8E-11 78
GO:0009893 Positive regulation of metabolic process 3.84E-13 5.85E-11 79
GO:0009890 Negative regulation of biosynthetic process 3.84E-13 5.78E-11 80
GO:0000122 Negative regulation of transcription from RNA polymerase II promoter 5.25E-13 7.72E-11 82
GO:0051252 Regulation of RNA metabolic process 9.69E-13 1.39E-10 84
GO:0051172 Negative regulation of nitrogen compound metabolic process 1.07E-12 1.52E-10 85
GO:2000112 Regulation of cellular macromolecule biosynthetic process 1.14E-12 1.6E-10 86
GO:0080090 Regulation of primary metabolic process 1.39E-12 1.92E-10 87
GO:0010629 Negative regulation of gene expression 2.02E-12 2.68E-10 91
GO:0010556 Regulation of macromolecule biosynthetic process 3.09E-12 3.96E-10 94
GO:0045892 Negative regulation of transcription, DNA-templated 4.17E-12 5.29E-10 95
GO:1902679 Negative regulation of RNA biosynthetic process 4.83E-12 6.07E-10 96
GO:0019222 Regulation of metabolic process 1.56E-11 1.84E-9 102
GO:0051253 Negative regulation of RNA metabolic process 1.94E-11 2.25E-9 104
GO:0010468 Regulation of gene expression 1.35E-10 1.39E-8 117
GO:0010558 Negative regulation of macromolecule biosynthetic process 1.39E-10 1.41E-8 119
GO:0010604 Positive regulation of macromolecule metabolic process 1.49E-10 1.46E-8 123
GO:2000113 Negative regulation of cellular macromolecule biosynthetic process 3.62E-10 3.38E-8 129
  1. This table includes only the hypermethylation-specific GO process terms that form a common cluster, associated with nucleotide metabolism, RNA metabolism and transcription. The presented p-values are unadjusted and the threshold for significance is 4.15e-6 (Bonferroni). The rank denotes the placement of a given GO term in the list of all significant GO terms. For all statistically significant GO process terms, see Additional file 5.
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