Impact of PRMT5 and PRMT4 on genome wide gene expression. (A) Overlap between differentially expressed genes in both prmt5 and prmt4a;4b mutants (Log2 FC >|0,58| and FDR ≤ 0,1). (B) Representation Factor of genes co- regulated by PRMT5 and PRMT4s in the selected functional categories. *: indicates over-representation compared to random. Significance was assessed using a hypergeometric test (p ≤ 0,05). (C) Log2 Fold Change of representative genes co- regulated by PRMT5 and PRMT4s (FDR ≤ 0,1).