Figure 3
IPA Network. 119 unique probe sets were obtained through correlational analysis by coding UCMS BALB/cJ animals as group one and all other animals as group 2 at the stringent |R|>0.8 cut-off level. The results were uploaded on Ingenuity Pathway Analysis and a significant network centred on the Nfkb gene hub was returned. The Nfkb has been associated with proinflammatory cytokines, such as IL-1beta which have been implicated in the cellular and behavioral effects of stress response and in mood disorders. Regulation of Nfkb has further been suggested to modulate hippocampal neurogenesis. Nodes on the diagram color coded represent reference molecules, with red indicating a positive correlation value and green indicating a negative correlation value.