Figure 5
IPA from WGCNA Meta analysis results with the GENDEP project. In order to cross-validate the significant module from the WGCNA analysis and gain additional insight into molecular mechanism associated with stress, related phenotypes, the results from convergent gene-modules associated with stress response across the two, independent studies obtained with WGCNA meta-analysis were uploaded on IPA. IPA returned a highly scoring gene network clearly centered on the Ubiquitun-C (UBC) gene. Ubiquitin-C has been previously associated with mood disorders and it is also known to be a stress-inducible protein.