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Table 3 The 626 interaction hits from the ANOVA model using strain and stress as main effects, at the c threshold of q = 0.05 were uploaded on the Ingenuity Pathway Analysis database

From: Pervasive and opposing effects of Unpredictable Chronic Mild Stress (UCMS) on hippocampal gene expression in BALB/cJ and C57BL/6J mouse strains

Symbol Entrez gene name Affymetrix Location Type
Creb1 cAMP responsive element binding protein 1 1452529_a_at Nucleus transcription regulator
Crem cAMP responsive element modulator 1418322_at Nucleus transcription regulator
Fyn FYN oncogene related to SRC, FGR, YES 1448765_at Plasma Membrane kinase
Grik1 glutamate receptor, ionotropic, kainate 1 1427676_a_at Plasma Membrane ion channel
Homer1 homer homolog 1 (Drosophila) 1425671_at Plasma Membrane other
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 1450219_at Plasma Membrane G-protein coupled receptor
Il1b interleukin 1, beta 1449399_a_at Extracellular Space cytokine
Ncam1 neural cell adhesion molecule 1 1421966_at Plasma Membrane other
Npy neuropeptide Y 1419127_at Extracellular Space other
Ptpra protein tyrosine phosphatase, receptor type, A 1425340_a_at Plasma Membrane phosphatase
Vldlr very low density lipoprotein receptor 1417900_a_at Plasma Membrane transporter
  1. IPA revealed a group of 11 associated genes associated with a stress response phenotype, several of which have been previously associated with depression and depression-related phenotypes.