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Figure 2 | BMC Genomics

Figure 2

From: Functional characterization of BC039389-GATM and KLK4-KRSP1 chimeric read-through transcripts which are up-regulated in renal cell cancer

Figure 2

Description of read-through BC039389-GATM. (A) DNA: Genomic structure of BC039389 and GATM on the DNA (−) strand. RNA: Two isoforms are expressed from the genomic locus both utilizing the same alternative ATG in GATM exon 3 for putative protein translation. TaqMan assay positions and the positions targeted by siRNAs are indicated. (B) Differential expression of BC039389-GATM isoform 1 (BGv1) in tumor vs. normal kidney tissue (**p < 0.01, student’s t-test with Bonferroni correction). (C) Comparison of BGv1 and BGv2 expression in 14 frozen tumor/normal sample pairs using TaqMan assays.

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