Alterations in the most relevant oncogenes and tumor suppressors involved in UBC. (A) Comparison of mutation frequency in UBC lines and tumors. (B) Frequency of LOH or homozygous deletion of tumor supressor genes in UBC lines and tumors. (C) Association between FGFR3 mutation status and mRNA expression. (D) Association between INK4A copy status and mRNA expression. (E) Association between PTEN copy status and mRNA expression. HD = Homozygous deletion, LOH = Loss of heterozygosity, WT = Wild type.*P < 0.05 **P < 0.01.