Table 2 Power of the four tests of X-linked associations under various scenarios
From: X-inactivation informs variance-based testing for X-linked association of a quantitative trait
Simulation parameters | X-inactivation in heterozygous females | X-inactivation and additional noise in heterozygous females | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Standard | Variance | Weighted | Combined | Standard | Variance | Weighted | Combined | |||
N = 1000 | MAF = 0.1 | a = 0.1 | 26.7 | 5.3 | 28.8 | 21.3 | 26.6 | 18.0 | 28.0 | 33.8 |
N = 1000 | MAF = 0.3 | a = 0.1 | 53.8 | 6.5 | 54.2 | 42.4 | 52.0 | 28.9 | 53.3 | 63.4 |
N = 1000 | MAF = 0.1 | a = 0.2 | 75.7 | 7.5 | 75.9 | 54.5 | 73.3 | 24.4 | 73.3 | 72.2 |
N = 1000 | MAF = 0.3 | a = 0.2 | 98.1 | 11.1 | 98.2 | 85.9 | 97.9 | 39.0 | 98.1 | 96.5 |
N = 2000 | MAF = 0.1 | a = 0.1 | 47.5 | 5.9 | 48.2 | 28.4 | 45.0 | 29.3 | 45.9 | 56.8 |
N = 2000 | MAF = 0.3 | a = 0.1 | 82.4 | 6.9 | 82.4 | 56.3 | 81.8 | 45.4 | 82.4 | 87.2 |
N = 2000 | MAF = 0.1 | a = 0.2 | 96.3 | 10.6 | 96.3 | 82.4 | 94.6 | 41.1 | 95.1 | 95.1 |
N = 3000 | MAF = 0.1 | a = 0.1 | 63.8 | 5.7 | 64.0 | 39.1 | 62.1 | 39.5 | 62.1 | 73.6 |
N = 3000 | MAF = 0.3 | a = 0.1 | 94.7 | 7.0 | 94.7 | 72.8 | 93.2 | 58.8 | 93.5 | 96.4 |
N = 3000 | MAF = 0.1 | a = 0.2 | 99.6 | 12.5 | 99.6 | 94.1 | 99.3 | 54.3 | 99.3 | 99.1 |
N = 5000 | MAF = 0.1 | a = 0.1 | 85.4 | 6.6 | 85.5 | 59.4 | 83.6 | 57.5 | 84.6 | 92.2 |