Prognostic biomarker discovery using ENCAPP. (A) Distribution of regression coefficients for different human cancers. The red shaded area corresponds to the top 10 percentile. Significant modules are defined as those with coefficients in the red shaded area. (B) Enrichment of known cancer genes in the significant modules for the breast cancer (2002), breast cancer (2005), colon cancer and ovarian cancer datasets. (C) Examples of significant modules for the breast cancer (2002) and colon cancer datasets. Known cancer genes are depicted in red. (D) Examples of novel biomarker prediction for the breast cancer (2002) and colon cancer datasets.