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Table 1 Relationships between recurrence-associated pathways and clinicopathological variables in HBV-HCC

From: Recurrence-associated pathways in hepatitis B virus-positive hepatocellular carcinoma

  Pathways-based subgroups Recurrence analysis
     Univariate analysis  
Variables Low risk High risk P-value 1 Hazard ratio (95% CI) 2 Log rank
p-value 3
Gender (Male/Female) 52/14 65/11 0.406 0.563 (0.320 0.991) 0.0439
Age (<50 y/≥50 y) 26/40 27/49 0.763 1.056 (0.706 1.577) 0.790
Platelet (<170 × 109/L/≥170 × 109/L) 33/25 28/36 0.204 1.019 (0.675 1.538) 0.928
4AST (<40 IU/L/≥40 IU/L) 40/26 31/45 0.0287 1.096 (0.745 1.613) 0.639
4ALT (<40 IU/L/≥40 IU/L) 41/25 33/43 0.0397 1.003 (0.682 1.477) 0.984
Bilirubin (<1 mg/dL/≥1 mg/dL) 44/22 42/34 0.224 1.050 (0.708 1.556) 0.806
4AFP (<300 ng/mL /≥300 ng/mL) 41/25 52/23 0.469 0.976 (0.644 1.480) 0.912
Child-Pugh (A/B,C) 63/3 65/10 0.131 1.813 (0.967 3.401) 0.0596
UICC (I,II/III,IV) 39/25 50/22 0.389 1.519 (1.015 2.273) 0.0404
Size (<3 cm/≥3 cm) 14/52 12/64 0.538 2.178 (1.216 3.901) 0.00726
Number (Single/Multiple) 56/10 64/10 0.972 1.874 (1.135 3.094) 0.0125
Necrosis (No/Yes) 33/33 25/50 0.0664 1.565 (1.048 2.339) 0.0273
Edmondson’s grade (I,II/III,IV) 45/19 45/27 0.435 1.273 (0.974 1.665) 0.0764
Vein invasion (Absent/Present) 49/12 39/31 0.00501 1.787 (1.175 2.718) 0.00594
Lobular activity (No/Yes) 39/25 18/56 2.879 × 10 −5 1.770 (1.166 2.685) 0.00652
Capsule (Absent/Present) 47/19 64/11 0.0660 0.617 (0.374 1.017) 0.05603
Margin (<2 cm/≥2 cm) 35/31 51/23 0.0794 0.836 (0.557 1.256) 0.389
Cirrhosis (Absent/Present) 37/29 41/34 0.997 1.257 (0.853 1.852) 0.245
Recurrence-associated pathways - - - 2.843 (1.881 4.295) 2.416 × 10 −7
     Multivariate analysis  
Recurrence-associated pathways     3.220 (2.076 4.994) 1.760 × 10 −7
Number (Single/Multiple)     1.839 (1.095 3.089) 0.0212
Size (<3 cm/≥3 cm)     2.489 (1.288 4.808) 0.00666
Edmondson’s grade (I,II/III,IV)     1.769 (1.159 2.701) 0.00821
  1. 1 p-values were calculated using χ2 test.
  2. 2CI represents confidence interval.
  3. 3 p-values were calculated using the Cox Proportional Hazards Model.
  4. 4AST, aspartate aminotransferase; ALT, alanine aminotransferase; AFP, α-fetoprotein.
  5. Bold data indicate statistically significant values (p<0.05).