Figure 5

Protein levels in mevalonate pathway and carotenogenesis. According to the carbon source the mean value and SD of abundance for each protein was normalized to a value of 100. Each column graphic represents the growth phases studied (from left to the right: lag, early exponential, late exponential and stationary). In the column charts a color code was included to differentiate proteins found when X. dendrorhous was cultured with the different carbon sources: proteins in glucose (orange) and proteins in succinate (cyan). The pathways were adapted from the KEGG database. In the metabolic pathways, names are written in a color letters: mevalonate proteins (green), carotenogenesis proteins (orange), related pathway proteins (purple), carotenoids and intermediates (black). The carotenogenic genes are illustrated in italic letters. Statistical significant differences between samples from different carbon sources at the same growth phase are represented as stars (t-test p < 0.02) and triangles (Benjamini-Hochberg correction p < 0.05). Abbreviations: HMG: hydroxymetylgluraryl, CoA: coenzyme A, P: phosphate, IPP: isopentenyl pyrophosphate, IDI: isopentenyl diphosphate isomerase, DMAPP: dimethylallyl pyrophosphate, GPP: geranyl pyrophosphate, FPP: farnesyl pyrophosphate, GGPP: geranylgeranyl pyrophosphate, CPR: cytochrome P450 reductase.