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Table 3 Selected KEGG pathways enriched in MD-induced DMRs

From: Histone modifications induced by MDV infection at early cytolytic and latency phases

Histone

DPI

Line

KEGG pathway

Count

P-value

Adjusted p-value

FDR

H3K4me3

5

L72

gga04120:Ubiquitin mediated proteolysis

20

0.011523

0.258461

12.60988

 

10

L63

gga03040:Spliceosome

76

1.27E-07

1.83E-05

1.5x10−4

   

gga04120:Ubiquitin mediated proteolysis

66

0.070518

0.409344

57.98318

   

gga04110:Cell cycle

61

0.071502

0.39873

58.50744

H3K27me3

5

L72

gga04512:ECM-receptor interaction

21

5.79E-04

0.070325

0.667972

   

gga04080:Neuroactive ligand-receptor interaction

45

0.004334

0.239385

4.905434

   

gga04510:Focal adhesion

32

0.0364

0.540977

34.90982

   

gga04010:MAPK signaling pathway

37

0.052973

0.533259

46.75692

   

gga04310:Wnt signaling pathway

23

0.097339

0.6588

69.45459

 

10

L63

gga04080:Neuroactive ligand-receptor interaction

48

0.001017

0.12119

1.172739

   

gga04010:MAPK signaling pathway

38

0.041861

0.595512

39.09871

   

gga04510:Focal adhesion

32

0.042927

0.548881

39.87981

   

gga04310:Wnt signaling pathway

24

0.069217

0.679767

56.47578

  1. DPI: Days post infection; Count: Number of genes associated with pathway; FDR: False discovery rate. P-value, adjusted p-value and FDR were calculated using default parameters in DAVID [12,13].